Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Rubia cordifolia, commonly known as Indian madder or Manjistha, has a long history of use in traditional Ayurvedic and Chinese medicine, where it is valued for its purported blood-purifying, anti-inflammatory, and antimicrobial properties. In these traditional systems, Rubia cordifolia is often prescribed for skin infections, wounds, and conditions believed to be associated with "impure blood" or chronic infections. The root extracts have been topically applied and consumed in various preparations to support the body's response to bacterial infections.

Scientific studies investigating the antibacterial activity of Rubia cordifolia are limited, but some in vitro research has shown that extracts from the plant possess moderate inhibitory effects against certain Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Escherichia coli. However, the concentrations effective in laboratory studies are often higher than would be typically achieved in traditional use, and there is a lack of robust clinical trials in humans to substantiate these findings.

Overall, while there is some preliminary scientific evidence that aligns with its traditional use for bacterial infections, the bulk of support remains historical and ethnobotanical. The evidence is rated at 2, reflecting both the strong traditional backing and the limited, but suggestive, laboratory studies. More rigorous clinical research would be necessary to justify its use as a reliable antibacterial agent in modern medicine.

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