Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has garnered scientific interest for its potential role in supporting the immune system, including defenses against bacterial infections. It is well-established that vitamin D receptors are present on various immune cells, such as macrophages and dendritic cells, which are integral to the body’s response to pathogens. Laboratory and some clinical studies suggest that vitamin D can enhance the production of antimicrobial peptides like cathelicidin, which help the body combat bacterial invaders. Observational studies have linked low vitamin D levels to an increased susceptibility to infections such as tuberculosis, respiratory tract infections, and sepsis.

However, while there is mechanistic and epidemiological evidence supporting a role for vitamin D in immune function, the overall clinical evidence for its effectiveness in treating or preventing bacterial infections is mixed and not robust. Randomized controlled trials have generally shown modest or no benefit for vitamin D supplementation in reducing bacterial infection rates in otherwise healthy populations. Some subgroups, such as individuals with profound vitamin D deficiency or those at high risk for specific infections, may benefit more, but evidence remains inconsistent. As a result, vitamin D is not a standard therapy for bacterial infections, but may be considered as an adjunct in individuals with deficiency. The evidence rating of 2 reflects promising biological plausibility and some observational support, but insufficient consistent clinical trial data to warrant widespread use for this indication.

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Other ingredients used for Infection (bacterial)

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