Evidence supporting the use of: Alkylglycerols
For the health condition: Infection (viral)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alkylglycerols (AKGs), naturally occurring ether lipids found in high concentrations in shark liver oil and human bone marrow, have been studied for their potential immunomodulatory effects, including possible antiviral properties. Some in vitro and animal studies suggest AKGs can stimulate immune cells, such as macrophages and neutrophils, and enhance antibody production. Historically, AKGs gained attention in the mid-20th century when Swedish researchers reported improved outcomes in infection-prone children and adults supplemented with shark liver oil, which is rich in AKGs. However, these early studies were small and lacked rigorous controls.

More recent research has explored AKGs' effects on immune response and viral infections, but high-quality clinical trials in humans remain limited. A few small clinical studies have suggested a reduction in the frequency or severity of respiratory infections in individuals taking AKG supplements, but methodological limitations and inconsistent results prevent definitive conclusions. There is some laboratory evidence suggesting AKGs may interfere with viral replication or enhance host defenses, but these findings have not been robustly translated into clinical practice.

In summary, while there is preliminary scientific rationale and limited clinical data suggesting that alkylglycerols may support immune function and potentially help in viral infections, the overall quality and quantity of evidence is low. Larger, well-controlled human studies are necessary before AKGs can be recommended for this purpose with confidence.

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