Evidence supporting the use of: Betulinic acid
For the health condition: Infection (viral)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Betulinic acid is a naturally occurring pentacyclic triterpenoid found in the bark of several plant species, notably birch trees. It has attracted scientific interest due to its broad range of biological activities, including antiviral properties. Preclinical studies have demonstrated that betulinic acid can inhibit the replication of several viruses, including HIV, herpes simplex virus, and influenza virus. Most notably, modifications of betulinic acid have led to the development of derivatives such as bevirimat, which entered clinical trials as an HIV maturation inhibitor. However, these studies are primarily in vitro or in animal models, and clinical trials in humans have been limited and have not yet led to approved antiviral medications. There is sparse evidence for betulinic acid's effectiveness against other viral infections in humans, and no major health agencies currently recommend its use for viral infections. In summary, while there is some scientific validation—mainly at the preclinical level—for the antiviral potential of betulinic acid, robust clinical evidence is lacking, and its use for treating viral infections is not established in medical practice.

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Products containing Betulinic acid

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