Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Boneset (Eupatorium perfoliatum) has a long history of traditional use in North American herbal medicine, particularly among Native American and early European settlers. It was commonly used to alleviate symptoms of "breakbone fever" (dengue), influenza, and other febrile illnesses believed to be caused by viral infections. Traditional preparations included teas and tinctures aimed at reducing fever, relieving aches, and supporting the body's immune response during infections. The plant contains compounds such as sesquiterpene lactones and polysaccharides, which have been investigated for potential immunomodulatory properties in laboratory settings.

However, while there are some in vitro studies suggesting that certain constituents of boneset may exhibit antiviral or immune-enhancing effects, there is a lack of robust clinical trials in humans to confirm efficacy against viral infections. Most of the current support for boneset's use in viral infections derives from ethnobotanical records and anecdotal accounts rather than rigorous scientific validation. Therefore, its use today for this purpose is primarily justified by tradition, with limited scientific evidence to support its effectiveness or safety for treating viral infections.

As with many traditional remedies, caution is advised, as boneset can be toxic in high doses and may cause side effects such as nausea or liver toxicity. Always consult a healthcare provider before using herbal medicines for infectious diseases.

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