Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Diallyl disulfide (DADS) is a sulfur-containing compound primarily found in garlic (Allium sativum). The use of garlic and its extracts for treating infections, including viral infections, has a long tradition in various cultures worldwide. Historical texts and folk medicine practices frequently recommend garlic for its supposed “immune-boosting” and antimicrobial properties. The rationale behind this traditional use includes the observation that garlic consumption was associated with reduced incidence of illness and the belief that its pungent odor could “purify” the air and body.

Scientific investigations have demonstrated that DADS and related organosulfur compounds display antimicrobial activity, especially against bacteria and fungi. However, evidence specific to viral infections is considerably less robust. A limited number of in vitro studies suggest that DADS may inhibit the replication of certain viruses, such as influenza or herpes simplex virus, but these effects have not been consistently reproduced in animal models or human clinical trials. Furthermore, the concentrations required for antiviral effects in the laboratory often exceed those achievable through dietary garlic intake.

Overall, while the traditional use of garlic (and thus DADS) for infections is well documented, direct scientific evidence supporting the use of DADS specifically for viral infections in clinical settings remains weak. Most use is based on historical precedent rather than robust clinical validation.

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