Evidence supporting the use of: Glucan peptides
For the health condition: Infection (viral)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glucan peptides—specifically beta-glucans derived from sources like yeast, mushrooms, and some cereals—have been investigated for their immunomodulatory properties, which may be relevant to viral infections. Beta-glucans are known to stimulate components of the innate immune system, particularly macrophages, neutrophils, and natural killer (NK) cells. Several preclinical studies have demonstrated that beta-glucans can enhance antiviral defenses in animal models by promoting the production of cytokines and increasing the activity of immune cells. For example, some studies have shown that beta-glucans can enhance resistance to influenza and herpes simplex viruses in mice.

Human data, however, are limited. Small clinical trials suggest that supplementation with beta-glucans may reduce the incidence and severity of upper respiratory tract infections (URTIs), presumed to be of viral origin, especially in populations under physical or psychological stress. However, these studies are often small, use varying preparations, and do not consistently specify the viral pathogens involved. There is no robust evidence supporting the use of glucan peptides as a treatment for established viral infections in humans, nor are they a replacement for antiviral medications or vaccines. The overall evidence is suggestive but not definitive, and further well-controlled clinical trials are needed to confirm efficacy and safety in the context of viral infections.

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