Honeysuckle (Lonicera japonica), known as "Jin Yin Hua" in Traditional Chinese Medicine (TCM), has a long history of use for treating infections, particularly those caused by viruses. In TCM, honeysuckle is considered to have "heat-clearing" and "detoxifying" properties, and it is often prescribed for febrile illnesses, sore throat, influenza, and other symptoms suggestive of viral infections. The plant is commonly included in classic TCM formulas such as Yin Qiao San, which is used to treat early-stage viral respiratory infections.

Some modern studies suggest that honeysuckle extracts possess antiviral activity in vitro, particularly against influenza viruses and other respiratory pathogens. Certain compounds isolated from honeysuckle, such as chlorogenic acid and luteolin, have demonstrated inhibitory effects on viral replication in laboratory settings. Animal studies and limited clinical observations indicate potential benefits, but large, rigorous human clinical trials are lacking.

Overall, the use of honeysuckle for viral infections is primarily justified by tradition, supported by centuries of clinical use in East Asia. There is moderate preclinical evidence for antiviral effects, but definitive scientific validation in humans is insufficient. Thus, while traditional use is strong and supported by some laboratory research, evidence from high-quality clinical trials is limited, warranting a moderate evidence rating.