Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Immunoglobulin G (IgG) is one of the main classes of antibodies found in blood and extracellular fluid, and it plays a crucial role in the body's immune response to infections, including viral infections. The use of intravenous immunoglobulin (IVIG), which is a preparation of pooled IgG antibodies from the plasma of healthy donors, has been scientifically validated as a treatment for certain viral infections, especially in individuals with compromised or deficient immune systems. For example, IVIG is used in patients with primary immunodeficiencies who cannot produce adequate antibodies on their own and are therefore highly susceptible to recurrent and severe viral infections. In these cases, IVIG provides passive immunity by supplying broad-spectrum antibodies that can neutralize a range of viruses. Moreover, IVIG has been utilized in the management of specific viral infections such as cytomegalovirus (CMV), parvovirus B19, and enterovirus, particularly in immunocompromised hosts like transplant recipients or neonates. During outbreaks or pandemics (such as influenza or COVID-19), convalescent plasma—rich in IgG specific to the pathogen—has also been explored as a therapeutic option, with varying levels of evidence supporting its efficacy. Despite these uses, IVIG is not a first-line therapy for most viral infections in the general population due to cost, availability, and the preference for direct antiviral agents when available. Nevertheless, its scientific foundation in supporting or treating viral infections, particularly in specific patient populations, is well recognized in clinical practice and supported by clinical studies and guidelines.

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Other health conditions supported by immunoglobin G

Products containing immunoglobin G

Designs For Health IgGI Shield™ 105 grams