Evidence supporting the use of: Lactococcus rhamnosus
For the health condition: Infection (viral)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactococcus rhamnosus, more commonly referred to as Lactobacillus rhamnosus due to historic classification, has been studied for its effects on the immune system and its potential to modulate responses to infections, including viral infections. Several clinical and experimental studies have shown that certain strains, particularly L. rhamnosus GG, can enhance mucosal immunity and influence the body's response to viral pathogens, mainly in the context of respiratory and gastrointestinal infections.

For example, there is evidence from randomized controlled trials that L. rhamnosus GG supplementation may modestly reduce the duration or severity of viral gastroenteritis, especially in children. Some studies suggest it can decrease the incidence or duration of upper respiratory tract infections (URTIs), which are often viral in origin, though results are variable and not universally positive. The proposed mechanisms include stimulation of local and systemic immune responses, enhancement of mucosal barrier function, and production of antiviral substances.

It should be noted that most evidence is strain-specific and moderate in quality, with some studies showing no significant benefit. There is currently insufficient high-quality evidence to broadly recommend Lactococcus rhamnosus for the prevention or treatment of viral infections in all populations. However, there is enough scientific investigation to justify its use in some clinical contexts, particularly for viral diarrhea in children, though the overall effect size is small. More rigorous, large-scale studies are needed to establish definitive efficacy.

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