Evidence supporting the use of: Split Gills Fungus
For the health condition: Infection (viral)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Schizophyllum commune, commonly known as Split Gills Fungus, has a long history of use in traditional medicine, especially in Asian cultures, for supporting immune function and combating infections, including viral ones. Ethnomedicinal records from China, India, and other parts of Asia note its use in concoctions aimed at treating respiratory illnesses and general immune enhancement. The fungus contains bioactive polysaccharides, such as schizophyllan, which have demonstrated immunomodulatory effects in preclinical studies. While there is some preliminary scientific interest—schizophyllan, for example, has been noted for its ability to stimulate macrophages and enhance host resistance—most of this work is in the context of general immune support or as an adjunct in cancer therapy, not specifically for viral infection treatment. Direct, high-quality clinical evidence for its efficacy against viral infections in humans is lacking. Thus, while there is a rich tradition underpinning its use for infection-related purposes, scientific validation for its specific antiviral activity or benefit in viral infections is still limited. The traditional rating reflects the ethnobotanical and historical reports rather than robust modern clinical trials.

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