Evidence supporting the use of: Tylophorine
For the health condition: Infection (viral)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tylophorine is a natural alkaloid primarily isolated from plants of the Tylophora genus, such as Tylophora indica. Its traditional use in Ayurveda and other indigenous systems is mainly for respiratory and inflammatory conditions, not specifically viral infections. However, in recent years, preclinical scientific studies have investigated tylophorine’s antiviral properties. In vitro research has shown that tylophorine and its derivatives possess inhibitory activity against a range of viruses, including coronaviruses (such as SARS-CoV and SARS-CoV-2), dengue virus, and enteroviruses. The proposed mechanisms involve interference with viral replication and modulation of host cell signaling pathways.

Despite promising laboratory findings, there is currently no robust clinical evidence supporting the use of tylophorine in humans for treating viral infections. Most studies remain at the cell culture or animal model stage. There are no published randomized controlled trials or regulatory approvals for tylophorine as an antiviral drug in any country as of mid-2024. Therefore, while there is emerging scientific interest and some mechanistic rationale for its antiviral effects, the evidence base is limited and not yet sufficient for clinical recommendation.

In summary, tylophorine’s use for viral infections is justified by preliminary scientific research rather than traditional practice or strong clinical evidence. Its current evidence rating is 2/5, reflecting promising but still early-stage scientific findings.

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Products containing Tylophorine

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