Evidence supporting the use of: Vitamin A (vitamin A cetate)
For the health condition: Infection (viral)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin A (including its ester form, vitamin A acetate) has scientific support for its use in the context of certain viral infections, particularly measles. Vitamin A plays a crucial role in maintaining the integrity and function of epithelial tissues and the immune system. Deficiency in vitamin A is associated with increased susceptibility to infectious diseases, especially in children. The World Health Organization (WHO) recommends high-dose vitamin A supplementation for children with measles in regions where deficiency is common, as studies have shown it can reduce morbidity and mortality associated with the infection. The mechanism is believed to relate to its role in supporting mucosal barriers and enhancing immune responses.

However, the evidence for the use of vitamin A supplementation in treating or preventing other viral infections (such as common respiratory viruses, influenza, or COVID-19) is much less substantial. Clinical trials outside the context of measles have not consistently demonstrated a benefit, and routine supplementation for viral infections in well-nourished populations is not recommended by major health authorities. In summary, vitamin A is validated for use in treating measles and preventing severe outcomes in deficient populations, but its utility against most viral infections is not broadly supported by strong scientific evidence.

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