Synopsis

Source of validity: Scientific
Rating (out of 5): 3

5-Methyltetrahydrofolate glucosamine (5-MTHF GlcN) is a bioactive form of folate used as an alternative to folic acid, especially in clinical settings addressing infertility. Folate plays a well-established role in DNA synthesis, repair, and methylation—processes crucial for gametogenesis and early embryonic development. Scientific evidence supports the use of folate supplementation for women trying to conceive, primarily for the prevention of neural tube defects, but also for optimizing reproductive outcomes. Several studies have highlighted that some individuals carry polymorphisms in the MTHFR gene (e.g., C677T mutation), which impairs their ability to convert synthetic folic acid into the active 5-MTHF form. 5-MTHF supplementation bypasses this metabolic bottleneck, potentially improving outcomes in those with impaired folic acid metabolism. Some observational and interventional studies, particularly in women undergoing assisted reproductive technologies (ART), suggest that using 5-MTHF instead of folic acid may improve oocyte quality, embryo development, and clinical pregnancy rates, especially in MTHFR-mutated populations. However, while there is growing scientific rationale and moderate-quality evidence supporting 5-MTHF supplementation in specific subgroups (like those with MTHFR mutations), robust, large-scale randomized controlled trials directly correlating 5-MTHF glucosamine supplementation with improved infertility outcomes are still limited. Thus, its use is scientifically grounded, but the strength of evidence is moderate rather than definitive.

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