False Unicorn (Chamaelirium luteum) has a long-standing history of use in traditional North American herbal medicine, particularly among Native American communities and 19th-century eclectic physicians. It was commonly employed as a "uterine tonic" to address various female reproductive issues, including infertility, irregular menstruation, and threatened miscarriage. The root was believed to help balance hormones and support the female reproductive system, often being included in herbal formulas aimed at promoting fertility and preventing miscarriages.

However, the scientific evidence supporting these uses is extremely limited. There are no well-designed clinical trials evaluating the efficacy of False Unicorn root for infertility in humans. Most of the information available comes from traditional herbal texts, anecdotal reports, and case histories rather than controlled research. Modern herbalists sometimes continue to use False Unicorn in fertility blends based on this traditional knowledge, but major medical and scientific reviews do not recognize it as an evidence-based treatment for infertility.

In summary, the use of False Unicorn for infertility is primarily justified by traditional use rather than scientific validation, and the evidence rating for its effectiveness in this context is low.