Evidence supporting the use of: Five-leaf Chastetree
For the health condition: Infertility

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Five-leaf Chastetree (Vitex negundo) is traditionally used in several Asian medicinal systems, including Ayurveda, Unani, and folk medicine, to support fertility and reproductive health. Its leaves, roots, and seeds have been mentioned in classical texts as remedies for a range of reproductive disorders, such as irregular menstruation, infertility, and hormonal imbalances. The use of Vitex negundo for infertility is primarily based on its reputation as a tonic for the female reproductive system and its claimed ability to regulate menstrual cycles and alleviate symptoms associated with hormonal disturbances.

However, scientific evidence supporting these traditional claims is limited. The majority of modern pharmacological studies on Vitex negundo have focused on its anti-inflammatory, analgesic, and antioxidant properties, rather than direct effects on fertility. While some animal studies suggest possible hormonal modulation or protective effects on reproductive organs, clinical trials in humans specifically assessing its efficacy for infertility are lacking. It is important not to confuse Vitex negundo (Five-leaf Chastetree) with Vitex agnus-castus (Chasteberry), which has somewhat more scientific research regarding female fertility.

In summary, the use of Five-leaf Chastetree for infertility is justified by tradition, but scientific validation remains weak, with evidence mostly anecdotal or preclinical.

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