Evidence supporting the use of: Human Chorionic Gonadotropin
For the health condition: Infertility

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Human Chorionic Gonadotropin (hCG) has robust scientific validation for its use in the treatment of infertility, particularly in both men and women with specific reproductive disorders. In women, hCG is structurally similar to luteinizing hormone (LH) and is used to induce ovulation after follicular development has been stimulated with other medications such as clomiphene citrate, letrozole, or gonadotropins. The administration of hCG mimics the natural LH surge, triggering the release of a mature egg from the ovary, which is essential for timed intercourse or assisted reproductive techniques such as intrauterine insemination (IUI) and in vitro fertilization (IVF). Numerous randomized controlled trials and clinical guidelines endorse the use of hCG for ovulation induction.

In men, hCG is used to stimulate the testes to produce testosterone and support spermatogenesis, particularly in cases of hypogonadotropic hypogonadism. By acting as an LH analog, hCG promotes the Leydig cells in the testes to synthesize testosterone, which is vital for sperm production and secondary sexual characteristics. It is often used alone or in combination with follicle-stimulating hormone (FSH) to restore fertility in men with pituitary insufficiency. The effectiveness and safety of hCG in these contexts are well-documented in the scientific literature, and it is included in major endocrinology and fertility treatment guidelines.

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