Evidence supporting the use of: Vitamin B9 (calcium methyltetrahydrofolate)
For the health condition: Infertility

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, particularly in its active form as calcium methyltetrahydrofolate, has scientific support for its use in addressing certain aspects of infertility, especially among women. Folate is essential for DNA synthesis, repair, and methylation, all of which are crucial during gametogenesis and early embryonic development. Deficiencies in folate are associated with neural tube defects and other adverse pregnancy outcomes. Several studies show that adequate folate status is associated with improved fertility and reproductive outcomes. For example, research indicates that women undergoing assisted reproductive technologies (ART) with higher folate intake have higher rates of implantation, pregnancy, and live births. Calcium methyltetrahydrofolate, a bioavailable form of folate, is particularly beneficial for individuals with genetic polymorphisms (such as MTHFR mutations) that impair folic acid metabolism. There is also evidence that folate supplementation may improve oocyte quality and reduce the risk of ovulatory infertility. However, while folate is a well-established component of preconception care, direct evidence specifically linking calcium methyltetrahydrofolate supplementation to increased fertility in the general population is moderate rather than strong. The existing evidence supports its use, particularly in high-risk groups or those with known deficiencies, but large-scale randomized controlled trials directly targeting infertility outcomes with this specific form are limited.

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