Evidence supporting the use of: Vitamin B9 (methyltetrahydrofolate)
For the health condition: Infertility

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, specifically as methyltetrahydrofolate (5-MTHF), is scientifically supported in the context of infertility, particularly for women attempting to conceive. Folic acid (the synthetic form) and its active form, 5-MTHF, are critical for DNA synthesis, repair, and methylation, all essential processes in gametogenesis and early embryonic development. Supplementation with folate is well established for the prevention of neural tube defects, leading to routine recommendations for women trying to conceive. Emerging evidence also suggests that low folate status may contribute to infertility and poor reproductive outcomes in both men and women. Studies indicate that adequate folate intake improves oocyte quality, supports ovulation, and is associated with higher rates of pregnancy in women undergoing assisted reproductive technologies (ART), such as IVF. Furthermore, women with genetic variants such as MTHFR polymorphisms may have impaired folic acid metabolism, and supplementation with 5-MTHF is preferred in these cases to bypass metabolic bottlenecks. Though not all research shows a direct causative link between folate supplementation and improved fertility in all populations, the biological plausibility and positive clinical associations render 5-MTHF a justified adjunct in fertility support. However, evidence is moderate (not conclusive) and strongest for prevention of birth defects rather than direct treatment of infertility.

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