Evidence supporting the use of: Vitamin D
For the health condition: Infertility

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has gained attention in recent years for its possible role in supporting fertility, both in women and men. The scientific interest is primarily due to the presence of vitamin D receptors and metabolizing enzymes in reproductive tissues such as the ovaries, endometrium, placenta, and testes. Observational studies have found correlations between sufficient vitamin D levels and improved fertility outcomes, including higher rates of conception and live births, particularly in women undergoing assisted reproductive technologies (ART) like IVF. For example, some studies have shown that women with adequate vitamin D status are more likely to achieve pregnancy compared to those who are deficient. In men, vitamin D deficiency has been linked to lower sperm motility and quality.

However, while these associations are promising, the evidence is not yet robust. Most data come from observational or small interventional studies, and randomized controlled trials (RCTs) yield mixed results, with some showing benefits and others finding no significant effect. The mechanisms by which vitamin D could influence fertility include modulation of sex hormone production, endometrial receptivity, and immune function. Despite the biological plausibility and some supportive evidence, current clinical guidelines do not universally recommend vitamin D supplementation specifically for infertility unless there is a documented deficiency.

In summary, there is scientific interest and some preliminary evidence supporting vitamin D’s role in fertility, but the overall quality and consistency of the evidence is moderate to low (2/5). Supplementation is justified in cases of deficiency, but its generalized use for infertility remains to be fully validated.

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Other health conditions supported by vitamin D

Acne
Allergies (food)
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Alzheimer's Disease
Amenorrhea
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Anorexia
Apathy
Arrhythmia
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Crohn's Disease
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Dandruff
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Diabetes
Diabetic Retinopathy
Erectile Dysfunction
Estrogen (low)
Fatigue
Fibroids (uterine)
Fibromyalgia Syndrome
Fibrosis
Grave's Disease
Grief and Sadness
Hair (loss or thinning)
Hair Care (general)
Hashimoto's Disease
Headache (cluster)
Heart (weakness)
Hypertension
Hypothyroid
Infection
Infection (bacterial)
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Infertility
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Irritable Bowel Syndrome
Itching
Knees (weak)
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