Relationship: Inflammation and vitamin C

Evidence supporting the use of: Vitamin C
For the health condition: Inflammation

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin C (ascorbic acid) is commonly used to support or treat inflammation, and its use is primarily justified by scientific evidence, though the strength of that evidence is moderate. Vitamin C is a potent antioxidant, and it plays a crucial role in protecting cells from oxidative stress, which is a major contributor to inflammation. Laboratory studies have demonstrated that vitamin C can modulate inflammatory pathways by reducing levels of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Additionally, vitamin C is essential for immune system function, supporting both the innate and adaptive immune responses that can help manage inflammation. Clinical studies, however, have provided mixed results. Some randomized controlled trials and meta-analyses suggest that vitamin C supplementation may modestly reduce markers of inflammation such as C-reactive protein (CRP), particularly in individuals with low baseline vitamin C levels or chronic inflammatory conditions. For example, a 2019 meta-analysis in European Journal of Clinical Nutrition found a modest but significant reduction in CRP after vitamin C supplementation. However, the evidence is less robust in healthy individuals or those without vitamin C deficiency, and not all trials have shown benefit. In summary, while there is a scientific rationale and some clinical support for vitamin C’s use in modulating inflammation, the overall evidence is moderate, and its benefits are more pronounced in specific populations rather than universally applicable.

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Other ingredients used for Inflammation

2'-Fucosyllactose
7-hydroxymatairesinol (HMR)
acai berry
adrenal cortex
ajoene
akkermansia muciniphila
alfalfa
algal oil
allspice
aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
alpha-pinene
anchovies
green chiretta
annatto
anthocyanins
apple
apricot
arabinogalactan
arjun tree
ashwagandha
astaxanthin
astragalus
bacillus subtilis
waterhyssop
bamboo
barberry
barley
beet
myrobalan
benegut perilla (proprietary)
berberine
bergamot
berry flavor
beta and delta tocopherols
beta caryophyllene
beta-pinene
Beta-Glucan
beta-sitosterol
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium longum
bilberry
black cumin
black currant
black garlic
black pepper
radish
sesame
black tea
black walnut
blackberry
blueberry
bonito peptide
borage oil
boron
Indian frankincense
bovine
branched-chain amino acids
broccoli
bromelain
brussel sprouts
bupleurum falcatum
burdock
cabbage leaf
calamari oil
camu camu
canola oil
cassia bark
cat's claw
catechins
caterpillar mushroom
catjang cowpea
cauliflower
celery
chaga mushroom
champignon
chen pi
cherry
chia seed
chicory
Chinese salvia root
chlorella
chlorophyll
chokeberry
chrysin
chymotrypsin
cinnamon
cissus quadrangularis
citrus bioflavonoids
citrus pectin
citrus sinensis (proprietary)
coffee fruit
collagen
collard
colostrum
conjugated linoleic acid (CLA)
copper
Coptis chinensis
cordyceps
cryptoxanthin
cucumber
turmeric
curcumin
cuspidatum root
cyclodextrin
d-alpha tocopherol
delta-tocopherol
devil's claw
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dog rose
DPA (docosapentaenoic acid)
dyer’s woad root
endo-peptidase
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
exo-peptidase
fennel
fenugreek
fisetin
fish oil
fish protein
flaxseed
forskohlii root
fructooligosaccharides (FOS)
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
fu ling
fungal protease
gamma tocopherol
gardenia
genistein
ginger
glycitin
goldenseal
gooseberry
gotu kola
grape
greek mountain tea
green lipped mussel
green tea
guggul
heartwood
hesperetin
hesperidin
hibiscus
HMR lignan
horse chestnut
hyaluronic acid
immunoglobin G
Indian gum arabic tree
indole-3-carbinol
honeysuckle
knotweed
Japanese sophora
jujube
kale
kelp
krill oil
kudzu
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-taurine
lactobacillus brevis
lactobacillus casei
lactobacillus fermentum
lactobacillus gasseri
lactobacillus helveticus
lactobacillus lactis
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus salivarius
lactococcus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lignans
linoleic acid (LA)
lion's mane
lophatherum leaf
lovage
lutein
luteolin
lychee
mackerel
maitake mushroom
mango
mangosteen
maqui berry
marine lipid
marshmallow
matcha
medium chain triglycerides (MCT)
methylsulfonylmethane (MSM)
mixed carotenoids
moringa
myristoleate
n-acetyl-glucosamine
n-acetyl-cysteine (NAC)
naringin
nettle
niacinamide (vitamin B3)
nicotinamide riboside
spruce
oat
okra
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
ophiopogon root
orange
oyster mushroom
palmitoleic acid
papain
perilla
phospholipids
phytocannabinoids
pine bark
platycodon root
plum fruit
pollen
polygala root
pomegranate
pomelo
prebiotic blend (proprietary)
protease
butyric acid
psyllium
pumpkin
pyrroloquinoline disodium salt
quail egg
quercetin
quinoa
redcurrant
rehmannia glutinosa
reishi mushroom
resveratrol
rhubarb root
riboflavin (vitamin B2)
rose hips
rutin
safflower oil
sage
sardines
scrophularia root
secoisolariciresinol diglucoside
selenium
serratiopeptidase
shiitake mushroom
black ginger
slippery elm bark
soybean
spearmint leaf
specialized pro-resolving mediators (SPMs)
spinach
spirulina
stigmasterol
strawberry
streptococcus thermophilus
sulforaphane glucosinolate
tetrahydro iso-alpha acids
tocotrienols
tomato
trans-geranylgeraniol
trans-pterostilbene
tributyrin
almond fruit
trypsin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin A
vitamin B6
vitamin C
vitamin D
vitamin D3
vitamin E
seaweed
wasabia japonica
watercress
watermelon
wheat grass
whey protein
mulberry
white willow
xylooligosaccharides
yeast
zhejiang fritillary
zinc
β-nicotinamide mononucleotide (NMN)
bentonite
sarsaparilla
red clover
yellow root
suma
jiaogulan
boneset
mullein
parthenium
tangerine
typhonium
hyssop
cardamom
atractylodes
capsicum
neem tree
enicostemma littorale
pterocarpus marsupium
malabar nut
alpinia galangal
clerodendrum indicum
ferula assafoetida
hedychium spicatum
inula racemosa
anise
pistacia integerrima gall
tylophora
punarnava
commiphora
holarrhena antidysenterica
smilax
tinospora cordifolia
blackboard tree
caesalpinia crista
fumaria parviflora
picrorhiza kurroa
rubia cordifolia
swertia
bee pollen
chaff flower
lingzhi
lingusticum wallichii
goldenrod
yarrow
pau d'arco
prickly ash
fritillaria
morus
sunflower
myrrh
elecampane
root tuber
ferulic acid
silk tree
chrysanthemum
haliotis
juniper berries
solomon's seal
amber
broomrape
flowering quince
dioscorea
fern
ganoderma
sweetgums
lotus seed
oriental arborvitae
birch
dulse leaf
sheep's sorrel
royal jelly
Equol (proprietary)
queen of the meadow
guelder rose
anemarrhena asphodeloides
hydrangea
purslane
assam indigo
yucca
eucalyptus
wintergreen
coix
polyporus
aster root
gentiana macrophylla
cleavers
shepherd's purse
yerba mate
peach
noni
wood betony
biota seed
nopal
goji berry
white oak
abies spectabilis
horehound
amaranth
millet seed
algae
cocoa
AMP-activated protein kinase (AMPK)
ashitaba
gravel root
soursop
geranium
arnica
clematis
1,2-di-galloyl-4,6hexahydroxydiphenoyl-D-glucose
15,16-Dihydrotanshinone I
12-methylcarnosic acid
3,3'-dihydroxy-B-carotene-4,4'-dione
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
3-Isomangostin
5,7-Dimethoxyflavone
6-Paradol
7,4-Dimethoxyflavone
7,14-Hydroxy-Docosapentaenoic Acid
7-Methoxyflavone
7b-hydroxy, 17b-dihydro DHEA
7-Hydroxyfrullanolide
7-Methylrosmanol
8-Bromo-7-Methoxychrysin
Aralia
Avens
Arugula
Arjuna
Agarikon Mushroom
akebia
Apple Cider Vinegar
Antler
Agastache
Alseodaphne andersonii
Anamarrhena
Autumn elaeagnus
Adhumulone
Alpha-Humulene
Alpha-terpineol
Amethoflavone
Anatabine
Ankaflavin
Asiaticoside
Ardisia
Angelica
acacia
Agave
Agrimony
Apigenin
Aronia melanocarpa
Allicin
Antrodia camphorata
Antirrhinum majus
Aminopeptidase
Achyranthes
Auricularia
Anamu
Abrus
Alchornea
American Pawpaw
Asarum heterotropoides
Autumn Olive
Albizia
Antirrhinin
AHCC
Alchemilla
Aconite
Asafoetida
Ajuga
Aucubin
Andrographolide
Avocado
Anserina
Agmatine
Aloin
Ascophyllum nodosum
Amentoflavone
Aerva lanata
Agarwood
American Liverleaf
Anemone
Aquilegia formosa
Asam gelugor
Acacetin
Aegeline
Allophycocyanin
Alpha-Lipoic Acid
Astragaloside
Armillaria mellea
Alpha lactalbumin
Arrowroot
Aescin
Aureobasidium pullulans
anthocyanidins
Andrographis
Adzuki bean
Ampelopsin
Alkanet
Alsonia scholaris
Ampelopsis
Actaea spicata
Agonandra
Agrimonia pilosa
Allyl Sulfide
Acemannan
Alpha phytosterol
Acetylsalicylic acid
Algal protein
Acer Truncatum bunge
Arjunic Acid
allyl isothiocyanate
Aspen
Adenophora
Alliin
anthocyanosides
Arabinoxylan
Ananain
Argan nut oil
Anemarrhena
Asarabacca
Acinetobacter lwoffii
Abuta
Alkanna
Allium tuberosum
Alstonia macrophylla
Amor seco
Aniseed myrtle
Arani
Arisaema
Asarum sieboldii
Alantolactone
Apocynin
Arctiin
Arjunolic acid
Artepillin C
Astragalin
Atractylone
Bee Propolis
Betony
Black Seed
Bifidobacterium
Bermuda Grass
Brassaiopsis glomerulata
Baikal Skullcap
Blue Flag
Bryonia
Buglossoides arvensis
Boston Ivy
Bifidobacterium adolescentis
Biopeptide
Bai Ji
Baliospermum
Black spruce
Blackthorn
Bridges' Penstemon
Broussonetia
Bulnesia sarmientoi
bergenin
Beta-hydroxybutyrate
Betulinic acid
Blubber oil
Breadnut
Blepharis
Brown Algae
Black-Eyed Susan
Balsam
Brassica
Boswellic Acid
Bayleaf
Belleric myrobalan
Blackbrush
Bistort
Black Locust
Baccharis dracunculifolia
Barleria
Berberis (unspecified)
Big Quaking Grass
Bok Choy
Bougainvillea
Brazillian peppertree
Bugbane
Baccosides
Baicalein
Beta-lapachone
Bisabolene
Benfotiamine
Bael
biochanin
Butternut
Basidiomycota
Begonia fimbristipula
Betanin
Bogbean
Black Gram
Bauhinia
Boswellia
Brazil nut
Black Poplar
Baccharoides anthelmintica
Backhousia citriodora
Banyan
Black willow
boysenberry
Butein
Brahmi
Bioflavonoids
Barbasco
black salt
Bifidobacterium animalis
Barbary matrimony vine
Black Nightshade
Borassus Palm
Buddha's Hand
Borassus aethiopum
Bitter principals
Babassu
Bacteria
Blue-Green Alage
Borage
bovine cartilage / glycosaminoglycan
Black root
Baobab
Bupleurum
Bacillus
Bittersweet
bacoside
benzyl isothiocyanate
Baicalin
Buckwheat
Bassia scoparia
Burning Bush
Black Hellebore
Bee venom
Balloon Flower
Belamcanda
Bergenia
Bignay
Bottle gourd
Beta-glucogallin
Bird's nest
Chia seed
Caffeic Acid
Cumin
Centaury
Coumarin
Centella triterpenes
Chinese Silkvine
Cowpea
Calendula
Casearia esculenta
Crocin
Common Eelgrass
Croton seeds
Chinese Mountain Ant
Crustaceans
Cyanobacteria
California Redbud
Calotropis gigantea
Carqueja
Carrapicho
Chervil
Clerodendrum trichotomum
Cloudberry
Carnosine
Calycosin
Catalpol
Chebulic acid
Camelina Oil
coconut oil
Cod Liver Oil
Cortisol
Coriolus mushroom
Costaria costata
Codonopsis
Coriander
Cnidium
Clerodendrum phlomidis
Cactus
Carvacrol
Cynomorium
Cape Aloe
Cinquefoil
Cyathula
Citron
Cashew
Cyanidin
chlorogenic acid
Chinese Fleeceflower
Cineole
Cymbidium goeringii
Cichoric acid
Cornflower
Cannabinol
Cramp Bark
Chinese Pond Turtle
Cajuput
Canaigre
Cereal grass
Chlorophytum
Chuchuhuasi
Common Zinnia
Cruciferous
Cyclanthera pedata
Casticin
Chitin-Glucan Complex
Caulerpa okamurae
Chordaria cladosiphon
Catechu
Cymbopogon Martini
Cyanotis Vaga
Centella asiatica
Capers
Celandine
Cinnamic Acid
Ceylon Leadwort
Cetylated Fatty Acids
Chard
Cissus sicyoides
Citral
Chinese Ligustrum berry
Creatine
Cinidium
Campylandra fimbriata
Chenopodium
Centipeda
Cistus
Corktree
Cubeb
Carnosol
Chalcone
Calanus finmarchicus
Chanterelle
Campsiandra angustifolia
C-Phycocyanin
cypress
Chaparral
Cabbage
Cowslip
Chirata
Cranesbill
Crinum latifolium
Cha de bugre
Chaenomeles lagenaria
Cannabidiol
Carlina
Calamus
Cirsium oligophyllum
Cherimoya
Chitin
Carotene (unspecified)
Chondracanthus chamissoi
Coin-leaf desmodium
Chinatree
Canihua
Chestnut
Cosmos
Cyanotis arachnoides
Cyanthillium cinereum
Corydalis
Chebulinic acid
Corilagin
Coumaric acid
Crocetin
Cynaropicrin
Cytokines
Cystoseira canariensis
Carambola
Cynodon dactylon
Cassava
Chiococca alba
Chekiang Fritillary
Collinsonia
Castor Oil
Carthamus
Celastrus
Copaiba Oil
Crypthecodinium
Colocynth
cola nut
Capsanthin
Clerodendrum indicum
Cade Juniper
Cupuacu
Casearia sylvestris
Catlaw Buttercup
Culvers Root
Currant
Calycophyllum
Carnosic acid
Cannabidiolic acid
Chondrus
Dunaliella salina
Dimorphandra mollis
Docosahexaenoic Acid
Didymocarpus
Dehydroabietic acid
Dendrobine
Diallyl sulfide
DIVI-DIVI
Dismutase
Danshen
Dense Fruit Dittany
Delphinidin
Dunaliella
Dihydromyricetin
Deer Root
Damulin A
Decursin
Decursinol
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dumontiaceae
Dragon Fruit
Durian
Daphne
Dibenzo-alpha pyrones
Dragonhead
Diosgenin
Drynaria
Dragon's Blood
Devil's Club
Dianthrone
Dwarf Morning Glory
Dolichos
Dihomo-gamma-linolenic acid
Didymin
Date
Dwarf Nettle
Dulse
Dithiolthiones
Desmodium
Dimethyl sulfoxide (DMSO)
Duckweed
Dimorphandra gardneriana
Diosmetin
Davilla rugosa
Deerbrush
Dichrostachys glomerata
Dipsacus
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
Epidermal Growth Factor
epicatechin
E-Viniferin
Ellagic Acid
European Elder
Erythropalum scandens
Erigeron
Eriocitrin
Erodium cicutarium
Eplotab
English Horsemint
Euryale seed
Ergothioneine
Elk antler
English Elm
Echinacea
Emblicanin
Ethylgallate
Eicosatetraenoic acid
Erythrodiol
European Field Elm
Echinodorus
Ecdysteroids
Eucheuma
Enzyme Blend
Eicosapentaenoic Acid
Euglena gracilis
Eupatorium
Euphorbia
Evening Primrose Oil
Escin
Elenolic acid
Eucommia ulmoides
Elemi
Echium
Embelia
Ellagitannin
Emodin
Eriodictyol
Eugenol
Ecklonia
Enokitake
Fig
Fiber
Finger-Leaf Morning Glory
Flavonones
Flammulina velutipes
Goldthread
Glycine
Glycosaminoglycans
Galangal
Ivy
Lotus
Lily
Little ironweed
Mallow
Milk Protein
Mistletoe
Mimosa
Orchid
omega-5 fatty acids
Prickly Pear Cactus
Pistachio
Quince
Quinoa Protein
Rose
Rhubarb
Spikenard
Snakeroot (unspecified)
Silk protein
Squash
Sumac
Sweet Orange alcohol
walnut

Other health conditions supported by vitamin C

Abrasions
Abscesses
Acne
Acquired Immune Deficiency Syndrome
Addictions (general remedies for)
Addison's Disease
Adrenal Fatigue
Age Spots
Aging (prevention)
Alcoholism
Allergies (food)
Allergies (respiratory)
Alzheimer's Disease
Anal Fistula or Fissure
Anemia
Antibiotics (alternatives to)
Antibiotics (side effects of)
Anxiety
Arteriosclerosis
Arthritis
Asthma
Athletic and Exercise Aids
Autism
Autoimmune Disorders
Bell's Palsy
Bites and Stings
Bladder Infection
Bleeding (external)
Bleeding (internal)
Blood Poisoning
Boils
Bronchitis
Bruises (healing)
Bruises (prevention)
Burns and Scalds
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Canker Sores
Capillary Weakness
Carbuncles
Cardiovascular Disease
Cartilage Damage
Cataracts
Cervical Dysplasia
Chemical Poisoning
Chemotherapy (reducing side effects)
Chicken Pox
Cholesterol (high)
Chronic Obstructive Pulmonary Disorder
Cold Sores
Colds (antiviral)
Colds (decongestant)
Colds (general)
Colds (prevention)
Colds (with fever)
Colon (atonic)
Congestion
Congestion (bronchial)
Congestion (lungs)
Congestion (sinus)
Conjunctivitis
Contagious Diseases
Convalescence
Copper Toxicity
Cough (dry)
Cough (general)
Cuts
Cystic Breast Disease
Cystic Fibrosis
Debility
Dementia
Denture Sores
Depression
Diabetes
Diabetic Retinopathy
Environmental Pollution
Epstein Barr Virus
Eye Problems
Eyesight (poor)
Fatigue
Fatty Liver Disease
Free Radical Damage
Gall Stones
Gastritis
Gingivitis
Glaucoma
Gonorrhea
Gout
Hair (loss or thinning)
Hair Care (general)
Heart (weakness)
Heavy Metal Poisoning
Hemorrhoids
Hepatitis
Herpes
Hot Flashes
Hypertension
Infection
Infection (bacterial)
Infection (viral)
Infertility
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Knees (weak)
Laryngitis
Lead Poisoning
Lesions
Leucorrhea
Leukemia
Ligaments (torn or injured)
Liver Detoxification
Lyme Disease
Macular Degeneration
Mastitis
Measles
Memory and Brain Function
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Metabolic Syndrome
Mononucleosis
Mumps
Nose Bleeds
Oral Surgery
Osteoporosis
Pancreatitis
PMS (general)
PMS Type C
PMS Type H
Pneumonia
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Prolapsed Uterus
Prostatitis
Radiation Sickness
Rashes and Hives
Restless Leg Syndrome
Rheumatoid Arthritis
Rhinitis
Rhinitis, Allergic
Rosacea
Scars / Scar Tissue
Schizophrenia
Scratches and Abrasions
Scurvy
Shingles
Shock
Sinus Infection
Skin (infections)
Skin Care (general)
Sore Throat
Spider Veins
Spinal Disks
Sprains
Strep Throat
Stretch Marks
Sunburn
Surgery (healing from)
Surgery (preparation for)
Teeth (loose)
Tendonitis
Thrush
Tickle in Throat
Tonsillitis
Tooth Extraction
Toxemia
Triglycerides (high)
Tuberculosis
Ulcerations (external)
Ulcers
Uric Acid Retention
Urinary Tract Infections
Vaginitis
Varicose Veins
Warts
Wounds and Sores
Wrinkles

Products containing vitamin C

Health Concerns

Brands

Evidence supporting the use of: Vitamin C
For the health condition: Inflammation

Table of Contents

Synopsis

Other ingredients used for Inflammation

Other health conditions supported by vitamin C

Products containing vitamin C

Health Concerns

Brands

Evidence supporting the use of: Vitamin CFor the health condition: Inflammation

Table of Contents

Synopsis

Other ingredients used for Inflammation

Other health conditions supported by vitamin C

Products containing vitamin C

Evidence supporting the use of: Vitamin C
For the health condition: Inflammation