Relationship: Inflammation and vitamin D3

Evidence supporting the use of: Vitamin D3
For the health condition: Inflammation

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D3 (cholecalciferol) has drawn significant attention for its potential role in modulating inflammation. Scientific research suggests that vitamin D3 impacts the immune system by interacting with vitamin D receptors (VDR) present on various immune cells, such as T cells, B cells, and macrophages. Several in vitro and animal studies have demonstrated that vitamin D can suppress the production of pro-inflammatory cytokines (such as TNF-α, IL-6, and IL-17) and promote anti-inflammatory cytokines (like IL-10). Furthermore, observational studies in humans have found that low levels of vitamin D are often associated with higher levels of markers of systemic inflammation such as C-reactive protein (CRP). However, while mechanistic studies and epidemiological data are suggestive, randomized controlled trials (RCTs) in humans have shown mixed results. Some RCTs demonstrate that vitamin D supplementation can reduce inflammatory markers in specific populations (such as those with chronic diseases or significant vitamin D deficiency), while others do not show significant benefits. The anti-inflammatory effects appear to be more robust in individuals with baseline vitamin D deficiency or with certain autoimmune conditions. In summary, there is scientific rationale and moderate evidence supporting vitamin D3 supplementation for the purpose of reducing inflammation, particularly in deficient individuals. However, more large-scale, high-quality trials are needed to clarify its efficacy and to determine optimal dosing and patient populations most likely to benefit.

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7-hydroxymatairesinol (HMR)
acai berry
adrenal cortex
ajoene
akkermansia muciniphila
alfalfa
algal oil
allspice
aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
alpha-pinene
anchovies
green chiretta
annatto
anthocyanins
apple
apricot
arabinogalactan
arjun tree
ashwagandha
astaxanthin
astragalus
bacillus subtilis
waterhyssop
bamboo
barberry
barley
beet
myrobalan
benegut perilla (proprietary)
berberine
bergamot
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beta and delta tocopherols
beta caryophyllene
beta-pinene
Beta-Glucan
beta-sitosterol
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium longum
bilberry
black cumin
black currant
black garlic
black pepper
radish
sesame
black tea
black walnut
blackberry
blueberry
bonito peptide
borage oil
boron
Indian frankincense
bovine
branched-chain amino acids
broccoli
bromelain
brussel sprouts
bupleurum falcatum
burdock
cabbage leaf
calamari oil
camu camu
canola oil
cassia bark
cat's claw
catechins
caterpillar mushroom
catjang cowpea
cauliflower
celery
chaga mushroom
champignon
chen pi
cherry
chia seed
chicory
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chlorella
chlorophyll
chokeberry
chrysin
chymotrypsin
cinnamon
cissus quadrangularis
citrus bioflavonoids
citrus pectin
citrus sinensis (proprietary)
coffee fruit
collagen
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conjugated linoleic acid (CLA)
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honeysuckle
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kudzu
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lactobacillus lactis
lactiplantibacillus plantarum
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lactococcus lactis
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omega-7 fatty acids
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fritillaria
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sunflower
myrrh
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allyl isothiocyanate
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bergenin
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bovine cartilage / glycosaminoglycan
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bacoside
benzyl isothiocyanate
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Chinese Pond Turtle
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Cinnamic Acid
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Cetylated Fatty Acids
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cypress
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Cha de bugre
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Cannabidiol
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Cherimoya
Chitin
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Chondracanthus chamissoi
Coin-leaf desmodium
Chinatree
Canihua
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Cyanotis arachnoides
Cyanthillium cinereum
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Chebulinic acid
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Cassava
Chiococca alba
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Crypthecodinium
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cola nut
Capsanthin
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Cade Juniper
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Casearia sylvestris
Catlaw Buttercup
Culvers Root
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Calycophyllum
Carnosic acid
Cannabidiolic acid
Chondrus
Dunaliella salina
Dimorphandra mollis
Docosahexaenoic Acid
Didymocarpus
Dehydroabietic acid
Dendrobine
Diallyl sulfide
DIVI-DIVI
Dismutase
Danshen
Dense Fruit Dittany
Delphinidin
Dunaliella
Dihydromyricetin
Deer Root
Damulin A
Decursin
Decursinol
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dumontiaceae
Dragon Fruit
Durian
Daphne
Dibenzo-alpha pyrones
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Diosgenin
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Dragon's Blood
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Dolichos
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Didymin
Date
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Dulse
Dithiolthiones
Desmodium
Dimethyl sulfoxide (DMSO)
Duckweed
Dimorphandra gardneriana
Diosmetin
Davilla rugosa
Deerbrush
Dichrostachys glomerata
Dipsacus
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
Epidermal Growth Factor
epicatechin
E-Viniferin
Ellagic Acid
European Elder
Erythropalum scandens
Erigeron
Eriocitrin
Erodium cicutarium
Eplotab
English Horsemint
Euryale seed
Ergothioneine
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Echinacea
Emblicanin
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Eicosatetraenoic acid
Erythrodiol
European Field Elm
Echinodorus
Ecdysteroids
Eucheuma
Enzyme Blend
Eicosapentaenoic Acid
Euglena gracilis
Eupatorium
Euphorbia
Evening Primrose Oil
Escin
Elenolic acid
Eucommia ulmoides
Elemi
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Embelia
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Emodin
Eriodictyol
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Flammulina velutipes
Goldthread
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Lotus
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Milk Protein
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Mimosa
Orchid
omega-5 fatty acids
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Pistachio
Quince
Quinoa Protein
Rose
Rhubarb
Spikenard
Snakeroot (unspecified)
Silk protein
Squash
Sumac
Sweet Orange alcohol
walnut

Products containing vitamin D3

Health Concerns

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Evidence supporting the use of: Vitamin D3
For the health condition: Inflammation

Table of Contents

Synopsis

Other ingredients used for Inflammation

Other health conditions supported by vitamin D3

Products containing vitamin D3

Health Concerns

Brands

Evidence supporting the use of: Vitamin D3For the health condition: Inflammation

Table of Contents

Synopsis

Other ingredients used for Inflammation

Other health conditions supported by vitamin D3

Products containing vitamin D3

Evidence supporting the use of: Vitamin D3
For the health condition: Inflammation