Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-keto-boswellic acid (AKBA) is a bioactive compound derived from Boswellia serrata, commonly known as Indian frankincense. AKBA is one of several boswellic acids that have attracted interest for their anti-inflammatory properties. Scientific research indicates that AKBA inhibits 5-lipoxygenase, an enzyme involved in the synthesis of leukotrienes, which are key mediators in the inflammatory process central to Inflammatory Bowel Disorders (IBD) such as Crohn’s disease and ulcerative colitis. Several preclinical studies using cell lines and animal models of colitis have shown that AKBA can reduce inflammation, decrease leukocyte infiltration, and protect intestinal tissue from damage. A few small clinical trials and pilot studies of Boswellia serrata extracts (which contain AKBA as a major active constituent) have reported improvements in IBD symptoms, with some studies suggesting comparable efficacy to standard therapies like sulfasalazine. However, these studies often used whole extracts rather than purified AKBA, and were limited by small sample sizes and methodological shortcomings. Larger, high-quality clinical trials of purified AKBA in IBD patients are lacking. Therefore, while there is a scientific rationale and some preliminary evidence, the overall strength of evidence supporting AKBA specifically for IBD is modest and not yet sufficient for unequivocal clinical endorsement.

More about Alpha-keto-boswellic acid
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Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
akkermansia muciniphila
algal oil
aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
bacillus clausii
bacillus subtilis
barberry
barley
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
butyrate triglyceride
cat's claw
chamomile
citrus pectin
Coptis chinensis
turmeric
curcumin
dandelion
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
fish oil
flaxseed
fructooligosaccharides (FOS)
inulin
isomalto-oligosaccharide
l-glutamine
lactobacillus brevis
lactobacillus casei
lactobacillus crispatus
lactobacillus fermentum
lactobacillus gasseri
lactobacillus lactis
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lactococcus lactis
licorice root
luteolin
marshmallow
n-acetyl-glucosamine
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
pectin
peppermint oil
butyric acid
psyllium
reishi mushroom
saccharomyces boulardii
shiitake mushroom
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Urolithin A
vitamin C
vitamin D
vitamin D3
xylanase
xylooligosaccharides
zinc
bentonite
punarnava
rubia cordifolia
swertia
myrrh
algae
7,14-Hydroxy-Docosapentaenoic Acid
Apigenin
Andrographolide
Avocado
anthocyanidins
Acemannan
Arabinoxylan
Apocynin
Arctiin
Astragalin
Bifidobacterium
Bifidobacterium adolescentis
Brassica
Boswellic Acid
Butternut
Basidiomycota
Boswellia
Bacillus licheniformis
Bioflavonoids
Bifidobacterium animalis
Bacteria
Bifidobacteria
Bacillus
Cichoric acid
Cruciferous
Casticin
Celandine
Chirata
Cannabidiol
Enterococcus
Eicosapentaenoic Acid
Ellagitannin
Fiber

Other health conditions supported by Alpha-keto-boswellic acid

Arthritis
Asthma
Autoimmune Disorders
Cancer (prevention)
Colitis
Inflammation
Inflammatory Bowel Disorders
Pain (general remedies for)
Rheumatoid Arthritis
Ulcers

Products containing Alpha-keto-boswellic acid

We currently have no products on Vitabase that contain this ingredient.