Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Butyric acid, also known as butyrate, is a short-chain fatty acid (SCFA) produced naturally in the colon by bacterial fermentation of dietary fibers. It has attracted considerable scientific interest for its potential role in supporting and treating Inflammatory Bowel Disorders (IBD), such as Crohn's disease and ulcerative colitis. Preclinical studies and some clinical trials suggest that butyrate has anti-inflammatory and trophic effects on colonocytes. Mechanistically, butyrate serves as the primary energy source for colon epithelial cells, promoting mucosal healing and supporting barrier integrity. It also modulates immune responses by inhibiting pro-inflammatory cytokine production and influencing regulatory T-cell function. Clinical studies, including small randomized controlled trials and observational studies, have explored the effects of oral or rectal butyrate supplementation in patients with IBD. Some report symptomatic improvement, reduced inflammation, and enhanced mucosal healing, particularly in cases of distal ulcerative colitis when administered as enemas. However, the overall quality of evidence is moderate, with mixed results across studies, limited sample sizes, and methodological variability. Current consensus guidelines do not universally endorse butyric acid as a first-line therapy for IBD, but its use is considered promising, especially as an adjunct to standard treatments. In summary, scientific evidence supports the rationale for butyric acid use in IBD, but further large-scale, high-quality clinical trials are required to establish its efficacy and optimal use.

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Other health conditions supported by butyric acid

Products containing butyric acid

Douglas Laboratories MCT/Butyrate Liquid with SunButyrate™