Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Casticin is a flavonoid compound found in various plants, most notably Vitex agnus-castus (Chaste tree). Its use for Inflammatory Bowel Disorders (IBD), which encompass Crohn’s disease and ulcerative colitis, is primarily supported by preclinical scientific research rather than traditional medicine. Several in vitro and animal studies have investigated casticin’s anti-inflammatory properties. For example, research has shown that casticin can inhibit the activation of NF-κB, a transcription factor involved in the expression of pro-inflammatory cytokines that play a key role in the pathogenesis of IBD. Studies in mouse models of colitis have demonstrated that casticin administration can reduce colon inflammation, decrease myeloperoxidase activity, and lower levels of inflammatory mediators such as TNF-α, IL-1β, and IL-6. However, these findings are limited to laboratory and animal models; to date, there are no published human clinical trials evaluating casticin for IBD. Therefore, while the current evidence suggests potential therapeutic effects via anti-inflammatory mechanisms, the evidence strength is rated 2/5: promising in preclinical settings but lacking direct clinical validation. Casticin is not established in traditional herbal medicine systems specifically for IBD, and its use for this purpose is grounded in emerging scientific rather than historical evidence.

More about casticin
More about Inflammatory Bowel Disorders

Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
7,14-Hydroxy-Docosapentaenoic Acid
Acemannan
Akkermansia muciniphila
Algae
algal oil
Aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
andrographolide
anthocyanidins
anthocyanins
apigenin
apocynin
arabinoxylan
arctiin
astragalin
avocado
Bacillus
bacillus clausii
Bacillus licheniformis
bacillus subtilis
bacteria
barberry
barley
Basidiomycota
bentonite
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bioflavonoids
Boswellia
Boswellic Acid
Brassica
butternut
butyrate triglyceride
butyric acid
cannabidiol
casticin
cat's claw
celandine
chamomile
chirata
cichoric acid
citrus pectin
Coptis chinensis
cruciferous
curcumin
dandelion
DHA (docosahexaenoic acid)
eicosapentaenoic acid
ellagitannin
Enterococcus
EPA (eicosapentaenoic acid)
fiber
fish oil
flavans
flaxseed
Frangula
fructooligosaccharides (FOS)
fucoidan
galactooligosaccharides
Glucosinolates
Glutathione
Glycomacropeptides
Glycosphingolipids
Glycyrrhetinic acid
Humic acid
inulin
isomalto-oligosaccharide
Kaempferol
L-glutamine
L. lactis
lactiplantibacillus plantarum
Lactobacillus
Lactobacillus brevis
Lactobacillus casei
Lactobacillus crispatus
Lactobacillus delbrueckii
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus johnsonii
Lactobacillus kefiranofaciens
Lactobacillus kefiri
Lactobacillus lactis
Lactobacillus paracasei
Lactobacillus pentosus
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus sakei
Lactobacillus salivarius
Lactococcus casei
Lactococcus lactis
Lactococcus rhamnosus
Legume protein
licorice root
luteolin
Marshmallow
Myrosinase
Myrrh
N-acetyl-cysteine (NAC)
N-acetyl-glucosamine
Neoandrographolides
nicotinamide riboside
Oligosaccharides
omega-3 fatty acids
Palmitoylethanolamide (PEA)
Pediococcus acidilactici
Pediococcus pentosaceus
Peppermint
phlorotannins
Piperine
polysaccharides
polyunsaturated fat
proanthocyanidins
probiotics
procyanidin
Propionibacterium freudenreichii
psyllium
punarnava
punicalagins
reishi mushroom
rosmarinic acid
Rubia cordifolia
Saccharomyces boulardii
shiitake mushroom
Slippery Elm
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
Sulfated polysaccharide
Sulforaphane
Swertia
Taraxasterol
Trametes
tributyrin
Tumerone
turmeric
Urolithin A
vitamin C
vitamin D
vitamin D3
Xylanase
xylooligosaccharides
Zinc

Other health conditions supported by casticin

Cancer (natural therapy for)
Cancer (prevention)
Infection (viral)
Inflammation
Inflammatory Bowel Disorders

Products containing casticin

We currently have no products on Vitabase that contain this ingredient.