Evidence supporting the use of: Eicosapentaenoic Acid
For the health condition: Inflammatory Bowel Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid predominantly found in fish oils. Its use in inflammatory bowel disorders (IBD), such as Crohn's disease and ulcerative colitis, is primarily based on its anti-inflammatory properties. EPA can be metabolized into eicosanoids that are generally less inflammatory than those derived from arachidonic acid. This mechanistic rationale has prompted investigation of EPA as a potential adjunctive therapy for IBD.

Scientific evidence for EPA's benefit in IBD is limited and mixed. Some early pilot studies and small-scale trials suggested that omega-3 supplementation, including EPA, might reduce relapse rates in Crohn's disease. However, larger randomized controlled trials, such as the EPIC-1 and EPIC-2 studies published in the New England Journal of Medicine (2008), failed to show a significant benefit of enteric-coated EPA-rich omega-3 fatty acids in maintaining remission in Crohn's disease. Evidence for ulcerative colitis is even less robust, with inconsistent results and few high-quality studies.

Systematic reviews and meta-analyses, including those by Cochrane, have concluded that there is insufficient evidence to recommend EPA or omega-3 fatty acids as effective therapy for IBD. While EPA is sometimes used in practice, this is not strongly supported by clinical trial data. Overall, the evidence supporting EPA's use in IBD is limited (rated 2/5), and current guidelines do not recommend it as a standard treatment.

More about Eicosapentaenoic Acid
More about Inflammatory Bowel Disorders

Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
akkermansia muciniphila
algal oil
aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
bacillus clausii
bacillus subtilis
barberry
barley
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
butyrate triglyceride
cat's claw
chamomile
citrus pectin
Coptis chinensis
turmeric
curcumin
dandelion
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
fish oil
flaxseed
fructooligosaccharides (FOS)
inulin
isomalto-oligosaccharide
l-glutamine
lactobacillus brevis
lactobacillus casei
lactobacillus crispatus
lactobacillus fermentum
lactobacillus gasseri
lactobacillus lactis
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lactococcus lactis
licorice root
luteolin
marshmallow
n-acetyl-glucosamine
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
pectin
peppermint oil
butyric acid
psyllium
reishi mushroom
saccharomyces boulardii
shiitake mushroom
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Urolithin A
vitamin C
vitamin D
vitamin D3
xylanase
xylooligosaccharides
zinc
bentonite
punarnava
rubia cordifolia
swertia
myrrh
algae
7,14-Hydroxy-Docosapentaenoic Acid
Apigenin
Andrographolide
Avocado
anthocyanidins
Acemannan
Arabinoxylan
Apocynin
Arctiin
Astragalin
Bifidobacterium
Bifidobacterium adolescentis
Brassica
Boswellic Acid
Butternut
Basidiomycota
Boswellia
Bacillus licheniformis
Bioflavonoids
Bifidobacterium animalis
Bacteria
Bifidobacteria
Bacillus
Cichoric acid
Cruciferous
Casticin
Celandine
Chirata
Cannabidiol
Enterococcus
Eicosapentaenoic Acid
Ellagitannin
Fiber

Products containing Eicosapentaenoic Acid

We currently have no products on Vitabase that contain this ingredient.