Evidence supporting the use of: Glucosinolates
For the health condition: Inflammatory Bowel Disorders
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Glucosinolates are naturally occurring compounds found in cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts. Their use in supporting or treating Inflammatory Bowel Disorders (IBD), such as Crohn's disease and ulcerative colitis, has some basis in scientific research, although evidence remains limited and largely preclinical. Glucosinolates are metabolized into bioactive compounds like isothiocyanates and indoles, which have demonstrated anti-inflammatory and antioxidant properties in cell and animal models. Several studies have shown that these metabolites can modulate inflammatory signaling pathways, reduce oxidative stress, and possibly protect intestinal epithelial integrity.
For example, sulforaphane, a well-studied isothiocyanate derivative of glucoraphanin (a glucosinolate), has been shown in animal models to reduce colonic inflammation and improve markers of gut barrier function. Additionally, some epidemiological studies suggest that higher intake of cruciferous vegetables may be associated with a lower risk of developing IBD, though these findings are not definitive.
However, clinical studies directly assessing the efficacy of glucosinolates or their metabolites in IBD patients are sparse, and no consensus exists regarding their therapeutic value in humans. Most of the current evidence comes from laboratory or animal research, and more robust human trials are needed. Therefore, while there is a scientific rationale and some supportive data, the overall strength of evidence for using glucosinolates specifically to treat or support IBD in humans is modest (rated 2/5).
More about Glucosinolates
More about Inflammatory Bowel Disorders
Other ingredients used for Inflammatory Bowel Disorders
2'-Fucosyllactose7,14-Hydroxy-Docosapentaenoic Acid
Acemannan
Akkermansia muciniphila
Algae
algal oil
Aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
andrographolide
anthocyanidins
anthocyanins
apigenin
apocynin
arabinoxylan
arctiin
astragalin
avocado
Bacillus
bacillus clausii
Bacillus licheniformis
bacillus subtilis
bacteria
barberry
barley
Basidiomycota
bentonite
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bioflavonoids
Boswellia
Boswellic Acid
Brassica
butternut
butyrate triglyceride
butyric acid
cannabidiol
casticin
cat's claw
celandine
chamomile
chirata
cichoric acid
citrus pectin
Coptis chinensis
cruciferous
curcumin
dandelion
DHA (docosahexaenoic acid)
eicosapentaenoic acid
ellagitannin
Enterococcus
EPA (eicosapentaenoic acid)
fiber
fish oil
flavans
flaxseed
Frangula
fructooligosaccharides (FOS)
fucoidan
galactooligosaccharides
Glucosinolates
Glutathione
Glycomacropeptides
Glycosphingolipids
Glycyrrhetinic acid
Humic acid
inulin
isomalto-oligosaccharide
Kaempferol
L-glutamine
L. lactis
lactiplantibacillus plantarum
Lactobacillus
Lactobacillus brevis
Lactobacillus casei
Lactobacillus crispatus
Lactobacillus delbrueckii
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus johnsonii
Lactobacillus kefiranofaciens
Lactobacillus kefiri
Lactobacillus lactis
Lactobacillus paracasei
Lactobacillus pentosus
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus sakei
Lactobacillus salivarius
Lactococcus casei
Lactococcus lactis
Lactococcus rhamnosus
Legume protein
licorice root
luteolin
Marshmallow
Myrosinase
Myrrh
N-acetyl-cysteine (NAC)
N-acetyl-glucosamine
Neoandrographolides
nicotinamide riboside
Oligosaccharides
omega-3 fatty acids
Palmitoylethanolamide (PEA)
Pediococcus acidilactici
Pediococcus pentosaceus
Peppermint
phlorotannins
Piperine
polysaccharides
polyunsaturated fat
proanthocyanidins
probiotics
procyanidin
Propionibacterium freudenreichii
psyllium
punarnava
punicalagins
reishi mushroom
rosmarinic acid
Rubia cordifolia
Saccharomyces boulardii
shiitake mushroom
Slippery Elm
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
Sulfated polysaccharide
Sulforaphane
Swertia
Taraxasterol
Trametes
tributyrin
Tumerone
turmeric
Urolithin A
vitamin C
vitamin D
vitamin D3
Xylanase
xylooligosaccharides
Zinc
Other health conditions supported by Glucosinolates
Cancer (natural therapy for)Cancer (prevention)
Cancer Treatment (reducing side effects)
Diabetes
Inflammation
Inflammatory Bowel Disorders
Metabolic Syndrome
Ulcers