Evidence supporting the use of: Glycyrrhizic acid
For the health condition: Inflammatory Bowel Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycyrrhizic acid, a major bioactive compound from licorice root (Glycyrrhiza glabra), has been investigated for its potential benefits in Inflammatory Bowel Disorders (IBD), such as Crohn's disease and ulcerative colitis. Preclinical studies, primarily in animal models, indicate that glycyrrhizic acid exhibits anti-inflammatory effects relevant to IBD. Mechanistically, it appears to inhibit key inflammatory pathways, including NF-κB signaling, and reduce the expression of pro-inflammatory cytokines like TNF-α and IL-6. Several rodent studies have demonstrated that administration of glycyrrhizic acid or its derivatives can decrease colonic inflammation, reduce tissue damage, and improve clinical symptoms in chemically induced models of colitis. However, direct clinical evidence in humans is limited. Most studies to date are preclinical, with only a few small-scale or adjunctive clinical trials exploring the effects of licorice extracts (which contain glycyrrhizic acid) in IBD patients, and these often have methodological limitations. Due to these factors, the strength of evidence supporting glycyrrhizic acid’s use in IBD is modest, and it cannot be considered a standard therapy. Safety concerns also exist, as glycyrrhizic acid can cause pseudoaldosteronism, hypertension, and electrolyte imbalances with prolonged use. In summary, while scientific studies provide a rationale for further research, current evidence is insufficient to strongly recommend glycyrrhizic acid for IBD treatment.

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Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
akkermansia muciniphila
algal oil
aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
bacillus clausii
bacillus subtilis
barberry
barley
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
butyrate triglyceride
cat's claw
chamomile
citrus pectin
Coptis chinensis
turmeric
curcumin
dandelion
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
fish oil
flaxseed
fructooligosaccharides (FOS)
inulin
isomalto-oligosaccharide
l-glutamine
lactobacillus brevis
lactobacillus casei
lactobacillus crispatus
lactobacillus fermentum
lactobacillus gasseri
lactobacillus lactis
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lactococcus lactis
licorice root
luteolin
marshmallow
n-acetyl-glucosamine
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
pectin
peppermint oil
butyric acid
psyllium
reishi mushroom
saccharomyces boulardii
shiitake mushroom
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Urolithin A
vitamin C
vitamin D
vitamin D3
xylanase
xylooligosaccharides
zinc
bentonite
punarnava
rubia cordifolia
swertia
myrrh
algae
7,14-Hydroxy-Docosapentaenoic Acid
Apigenin
Andrographolide
Avocado
anthocyanidins
Acemannan
Arabinoxylan
Apocynin
Arctiin
Astragalin
Bifidobacterium
Bifidobacterium adolescentis
Brassica
Boswellic Acid
Butternut
Basidiomycota
Boswellia
Bacillus licheniformis
Bioflavonoids
Bifidobacterium animalis
Bacteria
Bifidobacteria
Bacillus
Cichoric acid
Cruciferous
Casticin
Celandine
Chirata
Cannabidiol
Enterococcus
Eicosapentaenoic Acid
Ellagitannin
Fiber

Products containing glycyrrhizic acid

We currently have no products on Vitabase that contain this ingredient.