Evidence supporting the use of: Neoandrographolides
For the health condition: Inflammatory Bowel Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Neoandrographolide is a diterpenoid compound derived from Andrographis paniculata, a medicinal plant traditionally used in Asian medicine. In the context of Inflammatory Bowel Disorders (IBD), such as Crohn's disease and ulcerative colitis, there is emerging scientific interest in neoandrographolide due to its anti-inflammatory and immunomodulatory properties. Several in vitro and in vivo animal studies have demonstrated that neoandrographolide can inhibit key pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6) and modulate the NF-κB signaling pathway, which plays a central role in intestinal inflammation. For instance, preclinical models of colitis in mice have shown that neoandrographolide administration reduced disease severity, lowered inflammatory markers, and improved histological outcomes in the colon.

However, there are currently no robust clinical trials in humans specifically addressing the efficacy or safety of neoandrographolide for IBD. Most available data are either preclinical or extrapolated from studies on the parent plant extract (Andrographis paniculata), which contains multiple active compounds. Although some small clinical studies have evaluated Andrographis extracts in ulcerative colitis with promising results, it is unclear to what extent neoandrographolide contributes to these effects. Thus, while the scientific rationale is supported by preliminary laboratory research, the clinical evidence in humans is limited, and more studies are needed to establish its therapeutic role in IBD.

More about Neoandrographolides
More about Inflammatory Bowel Disorders

Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
7,14-Hydroxy-Docosapentaenoic Acid
Acemannan
Akkermansia muciniphila
Algae
algal oil
Aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
andrographolide
anthocyanidins
anthocyanins
apigenin
apocynin
arabinoxylan
arctiin
astragalin
avocado
Bacillus
bacillus clausii
Bacillus licheniformis
bacillus subtilis
bacteria
barberry
barley
Basidiomycota
bentonite
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bioflavonoids
Boswellia
Boswellic Acid
Brassica
butternut
butyrate triglyceride
butyric acid
cannabidiol
casticin
cat's claw
celandine
chamomile
chirata
cichoric acid
citrus pectin
Coptis chinensis
cruciferous
curcumin
dandelion
DHA (docosahexaenoic acid)
eicosapentaenoic acid
ellagitannin
Enterococcus
EPA (eicosapentaenoic acid)
fiber
fish oil
flavans
flaxseed
Frangula
fructooligosaccharides (FOS)
fucoidan
galactooligosaccharides
Glucosinolates
Glutathione
Glycomacropeptides
Glycosphingolipids
Glycyrrhetinic acid
Humic acid
inulin
isomalto-oligosaccharide
Kaempferol
L-glutamine
L. lactis
lactiplantibacillus plantarum
Lactobacillus
Lactobacillus brevis
Lactobacillus casei
Lactobacillus crispatus
Lactobacillus delbrueckii
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus johnsonii
Lactobacillus kefiranofaciens
Lactobacillus kefiri
Lactobacillus lactis
Lactobacillus paracasei
Lactobacillus pentosus
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus sakei
Lactobacillus salivarius
Lactococcus casei
Lactococcus lactis
Lactococcus rhamnosus
Legume protein
licorice root
luteolin
Marshmallow
Myrosinase
Myrrh
N-acetyl-cysteine (NAC)
N-acetyl-glucosamine
Neoandrographolides
nicotinamide riboside
Oligosaccharides
omega-3 fatty acids
Palmitoylethanolamide (PEA)
Pediococcus acidilactici
Pediococcus pentosaceus
Peppermint
phlorotannins
Piperine
polysaccharides
polyunsaturated fat
proanthocyanidins
probiotics
procyanidin
Propionibacterium freudenreichii
psyllium
punarnava
punicalagins
reishi mushroom
rosmarinic acid
Rubia cordifolia
Saccharomyces boulardii
shiitake mushroom
Slippery Elm
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
Sulfated polysaccharide
Sulforaphane
Swertia
Taraxasterol
Trametes
tributyrin
Tumerone
turmeric
Urolithin A
vitamin C
vitamin D
vitamin D3
Xylanase
xylooligosaccharides
Zinc

Products containing Neoandrographolides

We currently have no products on Vitabase that contain this ingredient.