Evidence supporting the use of: Phlorotannins
For the health condition: Inflammatory Bowel Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phlorotannins are a class of polyphenolic compounds found exclusively in brown seaweeds. Their use for the support or treatment of Inflammatory Bowel Disorders (IBD), such as Crohn’s disease and ulcerative colitis, is primarily based on emerging scientific research rather than traditional use. Several preclinical studies have demonstrated that phlorotannins exhibit strong antioxidant and anti-inflammatory properties. In animal models of colitis, phlorotannins have been shown to reduce inflammation, decrease the production of pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6), and improve histopathological features of the colon. These effects are believed to be mediated through inhibition of the NF-κB signaling pathway and reduction of oxidative stress in intestinal tissues.

Despite these promising results in cell cultures and animal studies, there is currently a lack of robust clinical trials in humans investigating the efficacy of phlorotannins for IBD. Thus, while preclinical evidence supports their potential benefit, the evidence base is not yet strong enough to recommend their use as a therapeutic agent for IBD in humans. Further research, especially well-designed human clinical trials, is needed to confirm safety, efficacy, and appropriate dosage. Presently, phlorotannins are best considered as a compound of interest with potential rather than an established therapy for IBD.

More about phlorotannins
More about Inflammatory Bowel Disorders

Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
7,14-Hydroxy-Docosapentaenoic Acid
Acemannan
Akkermansia muciniphila
Algae
algal oil
Aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
andrographolide
anthocyanidins
anthocyanins
apigenin
apocynin
arabinoxylan
arctiin
astragalin
avocado
Bacillus
bacillus clausii
Bacillus licheniformis
bacillus subtilis
bacteria
barberry
barley
Basidiomycota
bentonite
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bioflavonoids
Boswellia
Boswellic Acid
Brassica
butternut
butyrate triglyceride
butyric acid
cannabidiol
casticin
cat's claw
celandine
chamomile
chirata
cichoric acid
citrus pectin
Coptis chinensis
cruciferous
curcumin
dandelion
DHA (docosahexaenoic acid)
eicosapentaenoic acid
ellagitannin
Enterococcus
EPA (eicosapentaenoic acid)
fiber
fish oil
flavans
flaxseed
Frangula
fructooligosaccharides (FOS)
fucoidan
galactooligosaccharides
Glucosinolates
Glutathione
Glycomacropeptides
Glycosphingolipids
Glycyrrhetinic acid
Humic acid
inulin
isomalto-oligosaccharide
Kaempferol
L-glutamine
L. lactis
lactiplantibacillus plantarum
Lactobacillus
Lactobacillus brevis
Lactobacillus casei
Lactobacillus crispatus
Lactobacillus delbrueckii
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus johnsonii
Lactobacillus kefiranofaciens
Lactobacillus kefiri
Lactobacillus lactis
Lactobacillus paracasei
Lactobacillus pentosus
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus sakei
Lactobacillus salivarius
Lactococcus casei
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Lactococcus rhamnosus
Legume protein
licorice root
luteolin
Marshmallow
Myrosinase
Myrrh
N-acetyl-cysteine (NAC)
N-acetyl-glucosamine
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nicotinamide riboside
Oligosaccharides
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Palmitoylethanolamide (PEA)
Pediococcus acidilactici
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Peppermint
phlorotannins
Piperine
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polyunsaturated fat
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shiitake mushroom
Slippery Elm
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specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
Sulfated polysaccharide
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Swertia
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Trametes
tributyrin
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turmeric
Urolithin A
vitamin C
vitamin D
vitamin D3
Xylanase
xylooligosaccharides
Zinc

Products containing phlorotannins

We currently have no products on Vitabase that contain this ingredient.