Evidence supporting the use of: Piperine
For the health condition: Inflammatory Bowel Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Piperine, the active alkaloid in black pepper (Piper nigrum), has been studied for its potential benefits in inflammatory bowel disorders (IBD), such as Crohn’s disease and ulcerative colitis. Preclinical research, primarily in animal models, demonstrates that piperine exhibits anti-inflammatory effects. These studies suggest that piperine can suppress the production of pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6), and inhibit the activation of nuclear factor-kappa B (NF-κB), a key regulator of inflammation in IBD. Additionally, piperine may reduce oxidative stress and protect intestinal mucosa from inflammatory damage.

However, evidence in humans is currently limited. Few, if any, clinical trials have directly assessed piperine supplementation in patients with IBD. Most data come from animal studies or in vitro experiments. While the mechanistic rationale is strong, and initial results are promising, the lack of robust human evidence means that piperine cannot be considered a proven therapy for IBD at this time. It is sometimes used as an adjunct in combination with other compounds (such as curcumin) to enhance bioavailability, but its standalone effects in human IBD remain uncertain.

In summary, the use of piperine for IBD is supported by preclinical scientific evidence, but current human data are insufficient to recommend it as a primary treatment. Further clinical studies are needed to establish its efficacy and safety in this context.

More about Piperine
More about Inflammatory Bowel Disorders

Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
7,14-Hydroxy-Docosapentaenoic Acid
Acemannan
Akkermansia muciniphila
Algae
algal oil
Aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
andrographolide
anthocyanidins
anthocyanins
apigenin
apocynin
arabinoxylan
arctiin
astragalin
avocado
Bacillus
bacillus clausii
Bacillus licheniformis
bacillus subtilis
bacteria
barberry
barley
Basidiomycota
bentonite
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bioflavonoids
Boswellia
Boswellic Acid
Brassica
butternut
butyrate triglyceride
butyric acid
cannabidiol
casticin
cat's claw
celandine
chamomile
chirata
cichoric acid
citrus pectin
Coptis chinensis
cruciferous
curcumin
dandelion
DHA (docosahexaenoic acid)
eicosapentaenoic acid
ellagitannin
Enterococcus
EPA (eicosapentaenoic acid)
fiber
fish oil
flavans
flaxseed
Frangula
fructooligosaccharides (FOS)
fucoidan
galactooligosaccharides
Glucosinolates
Glutathione
Glycomacropeptides
Glycosphingolipids
Glycyrrhetinic acid
Humic acid
inulin
isomalto-oligosaccharide
Kaempferol
L-glutamine
L. lactis
lactiplantibacillus plantarum
Lactobacillus
Lactobacillus brevis
Lactobacillus casei
Lactobacillus crispatus
Lactobacillus delbrueckii
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus johnsonii
Lactobacillus kefiranofaciens
Lactobacillus kefiri
Lactobacillus lactis
Lactobacillus paracasei
Lactobacillus pentosus
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus sakei
Lactobacillus salivarius
Lactococcus casei
Lactococcus lactis
Lactococcus rhamnosus
Legume protein
licorice root
luteolin
Marshmallow
Myrosinase
Myrrh
N-acetyl-cysteine (NAC)
N-acetyl-glucosamine
Neoandrographolides
nicotinamide riboside
Oligosaccharides
omega-3 fatty acids
Palmitoylethanolamide (PEA)
Pediococcus acidilactici
Pediococcus pentosaceus
Peppermint
phlorotannins
Piperine
polysaccharides
polyunsaturated fat
proanthocyanidins
probiotics
procyanidin
Propionibacterium freudenreichii
psyllium
punarnava
punicalagins
reishi mushroom
rosmarinic acid
Rubia cordifolia
Saccharomyces boulardii
shiitake mushroom
Slippery Elm
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
Sulfated polysaccharide
Sulforaphane
Swertia
Taraxasterol
Trametes
tributyrin
Tumerone
turmeric
Urolithin A
vitamin C
vitamin D
vitamin D3
Xylanase
xylooligosaccharides
Zinc

Products containing Piperine

We currently have no products on Vitabase that contain this ingredient.