Evidence supporting the use of: Polyphenols (mixed)
For the health condition: Inflammatory Bowel Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyphenols (mixed), a diverse group of naturally occurring compounds found in plants (such as flavonoids, phenolic acids, and lignans), are increasingly studied for their potential role in managing Inflammatory Bowel Disorders (IBD), including Crohn’s disease and ulcerative colitis. Preclinical studies (in vitro and animal models) have demonstrated that polyphenols can exert anti-inflammatory, antioxidant, and immunomodulatory effects. They appear to modulate inflammatory signaling pathways (e.g., NF-κB), downregulate pro-inflammatory cytokines, and reduce oxidative stress, all of which are implicated in the pathogenesis of IBD. Some small-scale clinical trials have begun to explore polyphenol-rich foods or extracts (such as green tea, curcumin, resveratrol, and cocoa flavonoids) in IBD patients, with some reporting improvements in clinical symptoms, disease activity scores, and markers of inflammation. However, these studies often have limitations such as small sample sizes, short durations, use of mixed polyphenol sources, and variability in polyphenol bioavailability. Systematic reviews (e.g., by the journal Nutrients, 2019; Frontiers in Nutrition, 2021) conclude that while preclinical evidence is strong, clinical evidence remains preliminary and further robust, large-scale trials are required. Thus, the use of mixed polyphenols to support IBD is grounded in scientific investigation, but current clinical evidence is moderate and not definitive. Polyphenols are not considered standard therapy but may serve as adjuncts under medical supervision.

More about Polyphenols (mixed)
More about Inflammatory Bowel Disorders

Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
akkermansia muciniphila
algal oil
aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
bacillus clausii
bacillus subtilis
barberry
barley
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
butyrate triglyceride
cat's claw
chamomile
citrus pectin
Coptis chinensis
turmeric
curcumin
dandelion
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
fish oil
flaxseed
fructooligosaccharides (FOS)
inulin
isomalto-oligosaccharide
l-glutamine
lactobacillus brevis
lactobacillus casei
lactobacillus crispatus
lactobacillus fermentum
lactobacillus gasseri
lactobacillus lactis
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lactococcus lactis
licorice root
luteolin
marshmallow
n-acetyl-glucosamine
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
pectin
peppermint oil
butyric acid
psyllium
reishi mushroom
saccharomyces boulardii
shiitake mushroom
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Urolithin A
vitamin C
vitamin D
vitamin D3
xylanase
xylooligosaccharides
zinc
bentonite
punarnava
rubia cordifolia
swertia
myrrh
algae
7,14-Hydroxy-Docosapentaenoic Acid
Apigenin
Andrographolide
Avocado
anthocyanidins
Acemannan
Arabinoxylan
Apocynin
Arctiin
Astragalin
Bifidobacterium
Bifidobacterium adolescentis
Brassica
Boswellic Acid
Butternut
Basidiomycota
Boswellia
Bacillus licheniformis
Bioflavonoids
Bifidobacterium animalis
Bacteria
Bifidobacteria
Bacillus
Cichoric acid
Cruciferous
Casticin
Celandine
Chirata
Cannabidiol
Enterococcus
Eicosapentaenoic Acid
Ellagitannin
Fiber

Products containing Polyphenols (mixed)

We currently have no products on Vitabase that contain this ingredient.