Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Procyanidins, a class of polyphenolic compounds abundant in foods like grapes, apples, and cocoa, have been investigated for their anti-inflammatory and antioxidant properties. There is emerging scientific interest in the potential of procyanidins to support or treat Inflammatory Bowel Disorders (IBD) such as Crohn’s disease and ulcerative colitis. Preclinical studies, primarily in animal models and cell cultures, suggest that procyanidins may help reduce intestinal inflammation by modulating inflammatory cytokine production, inhibiting NF-κB signaling, and protecting intestinal barrier function. For example, studies in mice have shown that procyanidin-rich extracts can attenuate colitis induced by chemicals like dextran sulfate sodium (DSS), with observed reductions in inflammatory markers and improvement in histological parameters.

However, evidence in humans is limited. There are very few clinical trials, and those that exist are small and preliminary. The majority of the data comes from animal or in vitro studies, which do not always translate to human efficacy. While the mechanistic rationale is plausible and preclinical results are promising, there is insufficient high-quality clinical evidence to support routine use of procyanidins for IBD. Thus, the scientific support is currently weak to moderate (rated 2/5), and procyanidins should not be considered a validated or primary therapy for IBD outside of research settings.

More about procyanidin
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Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
7,14-Hydroxy-Docosapentaenoic Acid
Acemannan
Akkermansia muciniphila
Algae
algal oil
Aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
andrographolide
anthocyanidins
anthocyanins
apigenin
apocynin
arabinoxylan
arctiin
astragalin
avocado
Bacillus
bacillus clausii
Bacillus licheniformis
bacillus subtilis
bacteria
barberry
barley
Basidiomycota
bentonite
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bioflavonoids
Boswellia
Boswellic Acid
Brassica
butternut
butyrate triglyceride
butyric acid
cannabidiol
casticin
cat's claw
celandine
chamomile
chirata
cichoric acid
citrus pectin
Coptis chinensis
cruciferous
curcumin
dandelion
DHA (docosahexaenoic acid)
eicosapentaenoic acid
ellagitannin
Enterococcus
EPA (eicosapentaenoic acid)
fiber
fish oil
flavans
flaxseed
Frangula
fructooligosaccharides (FOS)
fucoidan
galactooligosaccharides
Glucosinolates
Glutathione
Glycomacropeptides
Glycosphingolipids
Glycyrrhetinic acid
Humic acid
inulin
isomalto-oligosaccharide
Kaempferol
L-glutamine
L. lactis
lactiplantibacillus plantarum
Lactobacillus
Lactobacillus brevis
Lactobacillus casei
Lactobacillus crispatus
Lactobacillus delbrueckii
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus johnsonii
Lactobacillus kefiranofaciens
Lactobacillus kefiri
Lactobacillus lactis
Lactobacillus paracasei
Lactobacillus pentosus
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus sakei
Lactobacillus salivarius
Lactococcus casei
Lactococcus lactis
Lactococcus rhamnosus
Legume protein
licorice root
luteolin
Marshmallow
Myrosinase
Myrrh
N-acetyl-cysteine (NAC)
N-acetyl-glucosamine
Neoandrographolides
nicotinamide riboside
Oligosaccharides
omega-3 fatty acids
Palmitoylethanolamide (PEA)
Pediococcus acidilactici
Pediococcus pentosaceus
Peppermint
phlorotannins
Piperine
polysaccharides
polyunsaturated fat
proanthocyanidins
probiotics
procyanidin
Propionibacterium freudenreichii
psyllium
punarnava
punicalagins
reishi mushroom
rosmarinic acid
Rubia cordifolia
Saccharomyces boulardii
shiitake mushroom
Slippery Elm
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
Sulfated polysaccharide
Sulforaphane
Swertia
Taraxasterol
Trametes
tributyrin
Tumerone
turmeric
Urolithin A
vitamin C
vitamin D
vitamin D3
Xylanase
xylooligosaccharides
Zinc

Other health conditions supported by procyanidin

Arthritis
Cancer (prevention)
Cardiovascular Disease
Cholesterol (high)
Circulation (poor)
Diabetes
Diabetic Retinopathy
Free Radical Damage
Gingivitis
Hypertension
Inflammation
Inflammatory Bowel Disorders
Osteoporosis
Skin Care (general)
Varicose Veins
Wrinkles

Products containing procyanidin

We currently have no products on Vitabase that contain this ingredient.