Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Evidence for Propionibacterium freudenreichii shermanii in Inflammatory Bowel Disorders

Propionibacterium freudenreichii shermanii, a probiotic bacterium commonly used in cheese production, has recently attracted attention for its potential benefits in gut health, including inflammatory bowel disorders (IBD) such as Crohn's disease and ulcerative colitis. The scientific rationale for its use centers on its ability to produce short-chain fatty acids (SCFAs), particularly propionate and acetate, which have anti-inflammatory properties and support the integrity of the intestinal barrier.

Several preclinical studies (e.g., in vitro and animal models) have shown that P. freudenreichii can reduce inflammatory markers, modulate immune responses, and enhance gut epithelial health. For example, components like its surface-layer proteins and metabolites (notably SCFAs) have demonstrated immunomodulatory effects and the ability to suppress pro-inflammatory cytokine production.

However, clinical evidence in humans is limited. A few small pilot studies have evaluated the impact of P. freudenreichii or its metabolites in IBD patients, often as part of multi-strain probiotic formulations, with some reports of improved symptoms or reduced inflammation. Nevertheless, large-scale, well-controlled clinical trials are lacking, and the efficacy and safety profile of this specific probiotic in IBD remain to be fully established.

In summary, while there is a plausible scientific basis and encouraging preliminary data, the current level of evidence remains modest (rated 2/5). More rigorous clinical research is required before P. freudenreichii shermanii can be recommended routinely for IBD management.

More about Propionibacterium freudenreichii shermanii
More about Inflammatory Bowel Disorders

Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
akkermansia muciniphila
algal oil
aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
bacillus clausii
bacillus subtilis
barberry
barley
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
butyrate triglyceride
cat's claw
chamomile
citrus pectin
Coptis chinensis
turmeric
curcumin
dandelion
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
fish oil
flaxseed
fructooligosaccharides (FOS)
inulin
isomalto-oligosaccharide
l-glutamine
lactobacillus brevis
lactobacillus casei
lactobacillus crispatus
lactobacillus fermentum
lactobacillus gasseri
lactobacillus lactis
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lactococcus lactis
licorice root
luteolin
marshmallow
n-acetyl-glucosamine
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
pectin
peppermint oil
butyric acid
psyllium
reishi mushroom
saccharomyces boulardii
shiitake mushroom
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Urolithin A
vitamin C
vitamin D
vitamin D3
xylanase
xylooligosaccharides
zinc
bentonite
punarnava
rubia cordifolia
swertia
myrrh
algae
7,14-Hydroxy-Docosapentaenoic Acid
Apigenin
Andrographolide
Avocado
anthocyanidins
Acemannan
Arabinoxylan
Apocynin
Arctiin
Astragalin
Bifidobacterium
Bifidobacterium adolescentis
Brassica
Boswellic Acid
Butternut
Basidiomycota
Boswellia
Bacillus licheniformis
Bioflavonoids
Bifidobacterium animalis
Bacteria
Bifidobacteria
Bacillus
Cichoric acid
Cruciferous
Casticin
Celandine
Chirata
Cannabidiol
Enterococcus
Eicosapentaenoic Acid
Ellagitannin
Fiber

Other health conditions supported by Propionibacterium freudenreichii shermanii

Colitis
Inflammatory Bowel Disorders
Irritable Bowel Syndrome

Products containing Propionibacterium freudenreichii shermanii

We currently have no products on Vitabase that contain this ingredient.