Evidence supporting the use of: Punicalagins
For the health condition: Inflammatory Bowel Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Punicalagins are large polyphenol compounds predominantly found in pomegranate (Punica granatum) and are known for their antioxidant and anti-inflammatory properties. Their use in supporting or treating Inflammatory Bowel Disorders (IBD), such as Crohn's disease and ulcerative colitis, has been investigated in preclinical models. Several animal studies have demonstrated that punicalagins, or pomegranate extracts rich in punicalagins, can reduce inflammatory markers, decrease oxidative stress, and mitigate tissue damage in chemically-induced colitis models. The mechanisms suggested include inhibition of pro-inflammatory cytokines (such as TNF-α and IL-6), suppression of NF-κB signaling, and enhancement of intestinal barrier function. However, there is a lack of robust human clinical trial data directly assessing punicalagins for IBD. Most of the current evidence is from in vitro and animal studies, with only a few small pilot studies in humans examining pomegranate extracts (which contain various polyphenols including punicalagins) for general gut inflammation rather than diagnosed IBD. Therefore, while there is a scientific rationale and encouraging preclinical data, the evidence for efficacy in humans remains limited and preliminary. Additional well-controlled clinical trials are needed to establish clear therapeutic benefit in IBD patients.

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Other ingredients used for Inflammatory Bowel Disorders

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Acemannan
Akkermansia muciniphila
Algae
algal oil
Aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
andrographolide
anthocyanidins
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apigenin
apocynin
arabinoxylan
arctiin
astragalin
avocado
Bacillus
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bacillus subtilis
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barberry
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Basidiomycota
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Bifidobacteria
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bioflavonoids
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Brassica
butternut
butyrate triglyceride
butyric acid
cannabidiol
casticin
cat's claw
celandine
chamomile
chirata
cichoric acid
citrus pectin
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cruciferous
curcumin
dandelion
DHA (docosahexaenoic acid)
eicosapentaenoic acid
ellagitannin
Enterococcus
EPA (eicosapentaenoic acid)
fiber
fish oil
flavans
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Frangula
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fucoidan
galactooligosaccharides
Glucosinolates
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Glycomacropeptides
Glycosphingolipids
Glycyrrhetinic acid
Humic acid
inulin
isomalto-oligosaccharide
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L-glutamine
L. lactis
lactiplantibacillus plantarum
Lactobacillus
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Lactobacillus delbrueckii
Lactobacillus fermentum
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Legume protein
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Products containing punicalagins

We currently have no products on Vitabase that contain this ingredient.