Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Synopsis of Evidence Supporting Streptococcus thermophilus for Inflammatory Bowel Disorders

Streptococcus thermophilus is a probiotic bacterium commonly found in yogurt and fermented dairy products. Its use in managing Inflammatory Bowel Disorders (IBD), such as Crohn’s disease and ulcerative colitis, is supported by some scientific evidence, though the strength and consistency of the data are limited.

Several clinical studies and animal models have explored the effects of S. thermophilus (often in combination with other probiotics, such as in the multi-strain VSL#3 formulation) on gut inflammation and mucosal healing. The proposed mechanisms include modulation of the gut microbiota, enhancement of the intestinal barrier, and anti-inflammatory effects via suppression of pro-inflammatory cytokines.

Notably, some randomized controlled trials using VSL#3—which contains S. thermophilus alongside other species—have demonstrated benefits in inducing or maintaining remission in ulcerative colitis and pouchitis. However, isolating the effect of S. thermophilus alone is challenging, as most studies use it in combination with other probiotic strains. There is limited evidence from studies using S. thermophilus as a single agent for IBD.

Overall, while there is a scientific rationale and some clinical evidence supporting the use of S. thermophilus-containing probiotics for IBD, the quality and quantity of evidence specifically for S. thermophilus alone are modest. Thus, it receives a moderate evidence score, and further well-designed studies are needed to clarify its independent role.

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