Evidence supporting the use of: Flavones
For the health condition: Influenza

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavones are a class of plant-derived polyphenolic compounds found in various fruits, vegetables, and medicinal herbs. Their use in supporting or treating influenza is grounded primarily in scientific research, particularly preclinical studies. Flavones, such as apigenin, luteolin, and baicalein, have demonstrated antiviral activity against influenza viruses in vitro and in animal models. These compounds may inhibit influenza virus replication by interfering with viral entry, replication, and assembly, as well as by modulating host immune responses and reducing inflammation. For example, baicalein has been shown to inhibit neuraminidase activity, a key enzyme involved in viral release from host cells, and luteolin has been observed to suppress influenza virus-induced cytokine production. However, despite promising results in laboratory and animal studies, there is a lack of robust clinical evidence in humans to support the use of flavones for the prevention or treatment of influenza. No large-scale randomized clinical trials have definitively established their efficacy or safety in this context. While traditional medicine systems have used flavone-rich plants for respiratory infections, the current scientific validation for their specific use against influenza is limited to preclinical research. Therefore, while the evidence base is growing, the clinical relevance remains uncertain, and the overall evidence rating for their use in influenza is moderate to low.

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Products containing Flavones

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