Evidence supporting the use of: Honeysuckle (unspecified)
For the health condition: Influenza

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Honeysuckle (Lonicera japonica) has a long history of use in Traditional Chinese Medicine (TCM) for the treatment of febrile diseases, including influenza. In TCM, it is one of the chief ingredients in formulas such as “Yin Qiao San,” which is commonly used for early-stage colds and flus. Scientific research has begun to examine the underlying mechanisms and efficacy of honeysuckle against influenza viruses. Several in vitro and animal studies have demonstrated that extracts of Lonicera japonica possess antiviral properties, particularly against various strains of influenza virus. Some studies attribute this activity to compounds like chlorogenic acid and luteolin, which may inhibit viral replication or modulate the immune response. A notable study published in Cell Research (2015) found that a microRNA (miR2911) from honeysuckle could directly target influenza A virus genes in mice, reducing viral replication. However, clinical trials in humans are limited, and the methodological quality of these studies is often low. Meta-analyses indicate potential benefit when honeysuckle is used in combination with other herbs in TCM formulas, but the specific contribution of honeysuckle remains unclear. In summary, while preclinical data and traditional use suggest potential for influenza treatment, robust clinical evidence is lacking, resulting in a moderate but not strong scientific justification for its use.

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