Evidence supporting the use of: Immunoglobulin G
For the health condition: Influenza

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Immunoglobulin G (IgG) has been explored as a potential adjunctive therapy for influenza, particularly in severe or high-risk cases. The rationale is that IgG preparations, especially those derived from convalescent plasma or hyperimmune globulin, contain high titers of influenza-specific antibodies that could neutralize the virus and modulate immune responses. Historical use of convalescent plasma and immunoglobulin for influenza dates back to the 1918 influenza pandemic, where some uncontrolled studies suggested reduced mortality.

Modern scientific evidence, however, is limited and mixed. Some in vitro and animal studies have demonstrated neutralizing activity against influenza viruses. A few small clinical trials and case series, primarily during the H1N1 and H5N1 outbreaks, have suggested a potential benefit in reducing viral load and mortality. However, larger randomized controlled trials, including those using IVIG (intravenous immunoglobulin) not specifically enriched for anti-influenza antibodies, have not consistently shown significant clinical benefit in hospitalized patients with severe influenza.

Current guidelines generally do not recommend routine use of IgG or IVIG for influenza except in the context of clinical trials or specific immunodeficient populations. The overall quality of evidence is low to moderate, and more research is needed to clarify the role of immunoglobulin therapy in influenza treatment.

More about Immunoglobulin G
More about Influenza

Other ingredients used for Influenza

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gooseberry
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green chiretta
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honey loquat syrup
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Products containing Immunoglobulin G

We currently have no products on Vitabase that contain this ingredient.