Evidence supporting the use of: Japanese Honeysuckle
For the health condition: Influenza

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Japanese Honeysuckle (Lonicera japonica) has a long history of use in traditional Chinese medicine (TCM), where it is known as "Jin Yin Hua" and is commonly employed for its purported antiviral, antibacterial, and anti-inflammatory properties. Its traditional applications include the treatment of febrile diseases, sore throat, and influenza-like illnesses. However, scientific research in recent years has begun to elucidate potential mechanisms that may justify its use against influenza.

Several in vitro and animal studies have demonstrated that extracts of Japanese Honeysuckle, particularly the active component chlorogenic acid, can inhibit the replication of influenza viruses (such as H1N1) and modulate immune responses. A 2015 study published in Cell Research identified a microRNA (miR2911) in honeysuckle decoction that directly targets influenza A virus genes, inhibiting viral replication in vitro and in mice. Additional studies have noted the plant’s anti-inflammatory effects, which could help alleviate symptoms of viral infections.

Despite promising in vitro and preclinical results, large-scale, high-quality human clinical trials are lacking, and thus the evidence for efficacy in humans remains moderate. Overall, while Japanese Honeysuckle’s use for influenza is grounded in both tradition and emerging scientific data, clinical validation is still needed before it can be broadly recommended for this indication.

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