Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactoferrin is a multifunctional glycoprotein with known antiviral, antibacterial, and immunomodulatory properties. Its use in supporting or treating influenza is primarily justified by scientific research, although the evidence is still limited and largely preclinical. Several in vitro studies have demonstrated that lactoferrin can inhibit the replication of influenza viruses by binding directly to viral particles or host cell receptors, thereby preventing viral entry into cells. For example, research published in Antiviral Research (2009) showed that bovine lactoferrin could inhibit infection by several influenza subtypes in cell culture models. Animal studies also suggest a potential benefit, with lactoferrin administration reducing viral load and improving survival in influenza-infected mice.

However, clinical evidence in humans remains scarce. A few small pilot studies have indicated that lactoferrin supplementation may shorten the duration or reduce the severity of symptoms in viral upper respiratory infections, but these studies often combine various viruses and do not focus exclusively on influenza. Overall, while laboratory and animal research is promising and supports a plausible mechanism of action, large-scale clinical trials are lacking. Therefore, lactoferrin’s use for influenza is backed by early-stage scientific evidence, but it is not yet established as a standard treatment or preventive measure for influenza in humans.

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Products containing lactoferrin

Metagenics Probioplex® Intensive Care Powder