Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactoperoxidase is an enzyme naturally present in various secretions such as saliva, milk, and airway mucus, where it plays a role in the innate immune system. Its mechanism involves catalyzing the oxidation of thiocyanate ions in the presence of hydrogen peroxide, generating antimicrobial compounds (notably hypothiocyanite) that can inactivate a range of pathogens, including some viruses. Several in vitro studies have demonstrated that the lactoperoxidase system can inhibit replication of influenza viruses by disrupting viral envelopes or interfering with viral entry into host cells. For instance, research published in Antimicrobial Agents and Chemotherapy (1994) and Journal of Antimicrobial Chemotherapy (2007) showed antiviral activity against influenza A and other respiratory viruses in cell cultures. However, clinical studies in humans are limited, and there is insufficient evidence to confirm that exogenous administration of lactoperoxidase (e.g., in supplements or sprays) is effective for preventing or treating influenza in real-world settings. The use of lactoperoxidase for influenza is thus grounded in plausible biochemical mechanisms and preclinical data, but lacks robust clinical validation. Therefore, while there is a scientific rationale for exploring its use, the overall level of evidence is still low (2/5), and it should not be considered a proven or primary therapy for influenza at this time.

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Products containing lactoperoxidase

Metagenics Probioplex® Intensive Care Powder