Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ornithine alpha-ketoglutarate (OKG) has been investigated as a nutritional supplement for supporting recovery from injuries, particularly in contexts such as trauma, surgery, and burns. The rationale stems from its metabolic roles: ornithine is involved in the urea cycle, helping to detoxify ammonia, while alpha-ketoglutarate is part of the Krebs cycle and serves as a precursor for amino acid synthesis. OKG supplementation is thought to enhance protein synthesis, reduce muscle breakdown (catabolism), and potentially promote wound healing by providing substrates for tissue repair.

Some clinical studies, mostly in surgical or critically ill patients, suggest that OKG may improve nitrogen balance, support immune response, and modestly enhance healing rates. For example, a few randomized controlled trials and reviews indicate that OKG can decrease protein catabolism and may reduce complications in trauma or burn patients. However, the quality and quantity of clinical evidence are limited, and studies often have small sample sizes or methodological weaknesses. There is also some evidence of benefit in elderly or malnourished patients.

Overall, while there is some scientific rationale and preliminary clinical support for the use of OKG in injury recovery, the evidence is not robust. It is rated as 2 out of 5 due to limited and inconsistent data. Larger, well-controlled trials are needed to confirm its efficacy and safety for treating or supporting injuries.

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