Evidence supporting the use of: Peptidase
For the health condition: Injuries
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Peptidases, also known as proteolytic enzymes or proteases, are enzymes that break down proteins into peptides and amino acids. They are found naturally in the body and in various foods and supplements (such as bromelain, papain, and serrapeptase). The use of exogenous peptidases to support or treat injuries, particularly musculoskeletal injuries, is supported by a moderate body of scientific evidence, though more high-quality studies are needed.
Several clinical studies have investigated the effects of proteolytic enzyme supplementation on inflammation, swelling, and pain following soft tissue injuries, surgery, or trauma. For example, bromelain (from pineapple) and serrapeptase (produced by bacteria in silkworms) have been shown in some randomized controlled trials to reduce post-injury or post-surgical swelling, improve pain scores, and accelerate recovery compared to placebo or standard treatments. The proposed mechanisms include the enzymes’ ability to reduce fibrin and other inflammatory mediators, thereby modulating the inflammatory response and promoting tissue remodeling.
However, the quality of the evidence is mixed, with some studies showing benefit and others showing minimal or no effect. Meta-analyses have concluded that proteolytic enzymes may be a useful adjunct for reducing swelling and improving functional recovery after injuries, but they are not a replacement for standard treatments. The safety profile is generally acceptable, but there are rare reports of gastrointestinal upset or allergic reactions. Overall, while not universally endorsed, the use of peptidases for injury support has a reasonable scientific basis but requires further large-scale trials to confirm efficacy.
Other ingredients used for Injuries
aloe veraamino acids
bamboo
bayberry
beeswax
Indian frankincense
bovine
bromelain
chymotrypsin
collagen
Coptis chinensis
turmeric
dandelion
dog rose
dyer’s woad root
endo-peptidase
exo-peptidase
fungal protease
ginger
l-alanyl-l-glutamine
l-glutamine
l-proline
licorice root
spruce
ornithine alpha-ketoglutarate
papain
protease
protein
purified silver
reishi mushroom
serratiopeptidase
silicon
trypsin
vitamin C
vitamin D
vitamin E
zinc
chickweed
typhonium
clerodendrum indicum
hedychium spicatum
chaff flower
boxthorne
yarrow
moss
myrrh
solomon's seal
amber
sheep's sorrel
wintergreen
fungal enzymes blend (proprietary)
abies spectabilis
geranium
arnica
Aralia
Avens
Asclepias cordifolia
akebia
Animal Tissue
Antler
Aquilegia viridiflora
Asiaticoside
Ardisia
Agave
Agrimony
Achyranthes
Anamu
Abrus
Albizia
Aconite
Ajuga
Aucubin
Anserina
Albumin
American Liverleaf
Aquilegia formosa
Asam gelugor
Allantoin
Ampelopsis
Agonandra
Agrimonia pilosa
Acemannan
Acetylsalicylic acid
Abuta
Alkanna
Alstonia macrophylla
Amor seco
Arani
Animal protein
Bee Propolis
Biopeptide
Bai Ji
Baliospermum
Black spruce
Blackthorn
Bulnesia sarmientoi
Blubber oil
Blepharis
Black-Eyed Susan
Boswellic Acid
Beef Protein
Barleria
Bone Marrow
Bovine Protein
Benzoin
Begonia fimbristipula
Banyan
Bletilla
Black root
Comfrey
Centella triterpenes
Calendula
Casearia esculenta
Common Monkey Flower
Calotropis gigantea
Clerodendrum trichotomum
Cinquefoil
Cyathula
Ceylon Leadwort
Cedar
Campylandra fimbriata
Centipeda
cypress
Cranesbill
Chinese Thoroughwax
Carlina
Carrapichinho
Cedrus libani
Ceanothus integerrimus
Connective tissue growth factor
Cocklebur
Collinsonia
Castor Oil
Calyptridium umbellatum
Casearia sylvestris
Didymocarpus
Deer Root
Damulin A
Deer Velvet
Dragon's Blood
Devil's Club
Dianthrone
Dwarf Nettle
Dimethyl sulfoxide (DMSO)
Davilla rugosa
Deerbrush
Epidermal Growth Factor
Erythropalum scandens
Erigeron
Elephant Vine
Erodium cicutarium
Elk antler
Echinacea
Emu Oil
Euphorbia
Egg protein
Elastase
Oak
Snakeroot (unspecified)
Silk protein
Other health conditions supported by Peptidase
EdemaInflammation
Injuries
Surgery (healing from)
Wounds and Sores