Evidence supporting the use of: Trypsin
For the health condition: Injuries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Trypsin is a proteolytic enzyme commonly used in combination with other enzymes such as bromelain and chymotrypsin to support the treatment of injuries, particularly soft tissue injuries like sprains, strains, and contusions. The rationale for its use is based on its ability to break down proteins, which can help in the removal of necrotic tissue and the reduction of inflammation and edema in injured tissues. Several clinical studies, particularly from the mid-to-late 20th century, have demonstrated that proteolytic enzyme preparations (oral or topical) can reduce swelling, pain, and recovery time in trauma and sports injuries. For example, a randomized controlled trial published in the Journal of International Medical Research (2004) found that a combination of trypsin, bromelain, and rutoside significantly reduced pain and inflammation compared to placebo in patients with blunt injuries. The proposed mechanisms involve modulation of inflammatory mediators and enhanced resorption of proteinaceous debris at the injury site.

However, the quality of evidence is variable, with more recent systematic reviews noting methodological limitations in earlier studies and calling for larger, well-designed trials. Despite these limitations, the use of trypsin-based enzyme therapy is still supported by moderate scientific evidence (rated 3/5), and it remains a common adjunct in some countries for managing soft tissue injury. Its use is generally considered safe, though rare allergic reactions or gastrointestinal upset may occur.

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More about Injuries

Other ingredients used for Injuries

aloe vera
amino acids
bamboo
bayberry
beeswax
Indian frankincense
bovine
bromelain
chymotrypsin
collagen
Coptis chinensis
turmeric
dandelion
dog rose
dyer’s woad root
endo-peptidase
exo-peptidase
fungal protease
ginger
l-alanyl-l-glutamine
l-glutamine
l-proline
licorice root
spruce
ornithine alpha-ketoglutarate
papain
protease
protein
purified silver
reishi mushroom
serratiopeptidase
silicon
trypsin
vitamin C
vitamin D
vitamin E
zinc
chickweed
typhonium
clerodendrum indicum
hedychium spicatum
chaff flower
boxthorne
yarrow
moss
myrrh
solomon's seal
amber
sheep's sorrel
wintergreen
fungal enzymes blend (proprietary)
abies spectabilis
geranium
arnica
Aralia
Avens
Asclepias cordifolia
akebia
Animal Tissue
Antler
Aquilegia viridiflora
Asiaticoside
Ardisia
Agave
Agrimony
Achyranthes
Anamu
Abrus
Albizia
Aconite
Ajuga
Aucubin
Anserina
Albumin
American Liverleaf
Aquilegia formosa
Asam gelugor
Allantoin
Ampelopsis
Agonandra
Agrimonia pilosa
Acemannan
Acetylsalicylic acid
Abuta
Alkanna
Alstonia macrophylla
Amor seco
Arani
Animal protein
Bee Propolis
Biopeptide
Bai Ji
Baliospermum
Black spruce
Blackthorn
Bulnesia sarmientoi
Blubber oil
Blepharis
Black-Eyed Susan
Boswellic Acid
Beef Protein
Barleria
Bone Marrow
Bovine Protein
Benzoin
Begonia fimbristipula
Banyan
Bletilla
Black root
Comfrey
Centella triterpenes
Calendula
Casearia esculenta
Common Monkey Flower
Calotropis gigantea
Clerodendrum trichotomum
Cinquefoil
Cyathula
Ceylon Leadwort
Cedar
Campylandra fimbriata
Centipeda
cypress
Cranesbill
Chinese Thoroughwax
Carlina
Carrapichinho
Cedrus libani
Ceanothus integerrimus
Connective tissue growth factor
Cocklebur
Collinsonia
Castor Oil
Calyptridium umbellatum
Casearia sylvestris
Didymocarpus
Deer Root
Damulin A
Deer Velvet
Dragon's Blood
Devil's Club
Dianthrone
Dwarf Nettle
Dimethyl sulfoxide (DMSO)
Davilla rugosa
Deerbrush
Epidermal Growth Factor
Erythropalum scandens
Erigeron
Elephant Vine
Erodium cicutarium
Elk antler
Echinacea
Emu Oil
Euphorbia
Egg protein
Elastase
Oak
Snakeroot (unspecified)
Silk protein