Evidence supporting the use of: Allyl isothiocyanate
For the health condition: Insect Repellant

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Allyl isothiocyanate (AITC), a compound found in mustard, horseradish, and wasabi, is scientifically validated as an effective insect repellent. Multiple laboratory and field studies have demonstrated its repellent and insecticidal properties. AITC acts as a natural defense mechanism for plants, deterring herbivorous insects by its pungent odor and irritant qualities. Research has shown that AITC can repel a variety of insect species, including mosquitoes, aphids, and stored-product pests. For example, a 2010 study published in Pest Management Science demonstrated significant repellency against mosquitoes and houseflies. Its mode of action involves activation of insect TRPA1 channels, causing sensory irritation and leading insects to avoid treated areas. Additionally, AITC has been explored as a potential alternative to synthetic chemical repellents due to its natural origin and low mammalian toxicity at repellant concentrations. However, while the preclinical and applied science is robust, commercialization for human topical use is limited by AITC’s strong odor and potential skin irritation. Nevertheless, there is clear scientific validation—supported by both laboratory and semi-field experiments—that allyl isothiocyanate possesses significant insect-repellent properties.

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Products containing Allyl isothiocyanate

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