Evidence supporting the use of: Calotropis gigantea
For the health condition: Insect Repellant

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Calotropis gigantea, commonly known as crown flower or giant milkweed, has demonstrated insect repellent properties in several scientific studies. The plant contains various bioactive compounds, including cardenolides, flavonoids, and triterpenoids, which have been evaluated for their ability to deter or kill insects. Laboratory research has shown that extracts from different parts of the plant—especially the leaves and latex—exhibit significant repellent and insecticidal activity against mosquito species such as Aedes aegypti and Anopheles stephensi. For example, ethanolic and methanolic extracts of Calotropis gigantea have been reported to provide moderate to high levels of repellency in bioassays, sometimes comparable to conventional repellents like DEET, though usually for shorter durations.

Additionally, the toxicity of the plant’s latex and its extracts to a variety of agricultural pests and vectors has been documented, supporting its potential as a botanical insecticide and repellent. However, most evidence comes from in vitro or small-scale laboratory studies; large-scale field trials and safety evaluations in humans are limited. Traditionally, parts of the plant have also been used in some cultures to keep insects away, but the scientific evidence now provides direct validation of its repellent properties. Thus, while further research is needed, Calotropis gigantea is scientifically supported as an insect repellent, with a moderate level of evidence (3/5) primarily from experimental studies.

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