Evidence supporting the use of: Isobutylamide
For the health condition: Insect Repellant

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Isobutylamides, particularly those derived from the plant Echinacea and other species, have demonstrated scientifically validated insect-repellent properties. The most well-known isobutylamide in this context is N,N-diethyl-meta-toluamide (commonly known as DEET), which is structurally related and has long been established as an effective insect repellent. However, specific isobutylamides from plants such as Zanthoxylum or Piper species (e.g., spilanthol) have been studied in vitro and in vivo for their capacity to repel mosquitoes and other biting insects.

Research indicates that isobutylamides can interfere with insect chemosensory mechanisms, thereby reducing the likelihood of bites. For example, spilanthol, an isobutylamide from Spilanthes acmella, has shown significant repellency against Aedes aegypti mosquitoes in laboratory settings. Studies published in peer-reviewed journals, such as Phytomedicine and Journal of Medical Entomology, have documented the efficacy of these compounds, although they are generally less potent and have shorter duration of action compared to DEET.

While isobutylamides are not as widely used in commercial repellents as DEET or picaridin, their use is increasingly supported by scientific literature, especially as interest grows in plant-based and natural alternatives. The evidence base is moderate to strong (rated 4/5), with multiple studies confirming repellent effects, but more large-scale, real-world trials are warranted before widespread adoption.

More about Isobutylamide
More about Insect Repellant

Other health conditions supported by Isobutylamide

Insect Repellant
Pain (general remedies for)

Products containing Isobutylamide

We currently have no products on Vitabase that contain this ingredient.