Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aminobutyric acid, most commonly referring to gamma-aminobutyric acid (GABA), is a neurotransmitter in the central nervous system with inhibitory effects. GABA plays a crucial role in reducing neuronal excitability and has been implicated in the regulation of sleep and anxiety. Scientific interest in GABA supplementation for insomnia arises because certain prescription hypnotic drugs (e.g., benzodiazepines) act on GABA receptors to promote sleep. However, the evidence supporting direct supplementation of GABA for insomnia is limited and mixed. Several small clinical trials have investigated oral GABA supplements for sleep improvement. Some studies suggest modest benefits, such as reduced sleep latency and improved subjective sleep quality, particularly in populations with mild insomnia. However, many of these studies have methodological limitations, including small sample sizes, short durations, and potential conflicts of interest. A significant challenge is that GABA, when taken orally, has limited ability to cross the blood-brain barrier, raising questions about its direct central effects. Overall, while the rationale for GABA supplementation is based on its known neurobiological role, current clinical evidence supporting its efficacy for insomnia is weak to moderate at best. Larger, well-controlled studies are needed to establish its effectiveness. Other forms of aminobutyric acid, such as beta-aminobutyric acid, have no established role in sleep support. Therefore, the scientific evidence for aminobutyric acid (unspecified) in treating insomnia is limited.

More about Aminobutyric acid (unspecified)
More about Insomnia

Other ingredients used for Insomnia

5-Hydroxytryptophan (5-HTP)
amino acids
ashwagandha
waterhyssop
benegut perilla (proprietary)
black cumin
Indian frankincense
rice
calcium
California poppy
cassia bark
chamomile
cherry
Chinese salvia root
cinnamon
Coptis chinensis
fennel
GABA (gamma aminobutyric acid)
gooseberry
gotu kola
greek mountain tea
heartwood
hops
jujube
kava root
kudzu
l-tryptophan
lactium casein decapeptide
lavender
maca
magnesium
magnolia
marine lipid
melatonin
moringa
motherwort
ophiopogon root
orange
passionflower
perilla
phytocannabinoids
pollen
polygala root
quail egg
reishi mushroom
rose oil
saffron
sage
scrophularia root
skullcap
valerian root
vitamin B6
zinc
catnip
tangerine
anise
blackboard tree
lingzhi
lingusticum wallichii
morus
silk tree
chrysanthemum
amber
ganoderma
lotus seed
anemarrhena asphodeloides
purslane
aster root
peach
wood betony
goji berry
soursop
Aralia
Agastache
Alpha-terpineol
Angelica
Apigenin
Anamu
Albizia
Agarwood
Anemone
Alpha lactalbumin
Agrimonia pilosa
Arani
Atractylone
Betony
Black Seed
Baikal Skullcap
Blackthorn
Balsam
Bayleaf
Big Quaking Grass
Banyan
Brahmi
Borassus Palm
Borassus aethiopum
Bupleurum
Centella triterpenes
Chinese Silkvine
Clary sage
Clerodendrum trichotomum
Cactus
Cyathula
Citron
Carry Me Seed
Cannabinol
Cymbopogon Martini
Calea zacatechichi
Centella asiatica
Capitate Valerian
Corktree
Cowslip
Cannabidiol
Calamus
Cherimoya
Corydalis
Carthamus
Clerodendrum indicum
Dragonhead
David's Milkberry
Doxylamine succinate
European Elder
Erodium cicutarium
Elk antler
Elephant's Head
Embelia
Glycine
jasmine
Lotus
Lily
Little ironweed
Mallow
Milk Protein
Mimosa
Orchid
Poppy
Rose
Spikenard
Sandalwood
Sumac
Sweet Orange alcohol
Vervain
walnut

Other health conditions supported by Aminobutyric acid (unspecified)

Anxiety
Epilepsy
Insomnia
Nervousness
Seizures
Sleep (restless and disturbed)
Stress
Tension

Products containing Aminobutyric acid (unspecified)

We currently have no products on Vitabase that contain this ingredient.