Griffonia simplicifolia is a West African plant whose seeds are a natural source of 5-hydroxytryptophan (5-HTP), a precursor to the neurotransmitter serotonin. Serotonin is involved in regulating mood and sleep cycles, and increased levels can promote the production of melatonin, a hormone that helps control sleep-wake cycles. This biochemical rationale underpins the use of Griffonia extract, particularly standardized 5-HTP supplements, for supporting sleep and managing insomnia.

Scientific evidence for Griffonia's efficacy in treating insomnia is limited, though some studies suggest a potential benefit. Clinical trials on 5-HTP (often derived from Griffonia) indicate possible improvements in sleep quality and reduced time to fall asleep. However, most studies are small, short-term, and of variable quality. A 2010 review (Sleep Medicine Reviews) concluded that while 5-HTP may have a role in sleep regulation, robust, high-quality evidence is lacking. Additionally, direct studies on Griffonia simplicifolia extract itself (not just purified 5-HTP) are sparse.

In summary, the scientific rationale for using Griffonia to support insomnia rests on its 5-HTP content and observed effects of 5-HTP supplementation. Preliminary clinical data are promising, but large, well-controlled trials are still needed to confirm efficacy and safety in this context.